All Phenotypes Olig1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Olig1⁺
wild type
MGI:2438771

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5800496
cn2	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3620048
cn3	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:6117077
cn4	Seh1l^tm1Lzha/Seh1l^tm1Lzha Olig1^tm1(cre)Rth/Olig1⁺	involves: 129S4/SvJae * C57BL/6	MGI:6712828
cn5	Olig1^tm1(cre)Rth/Olig1⁺ Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu	involves: 129S4/SvJaeSor * C57BL/6	MGI:7734972

Allelic Composition	Ncstn^tm1.1Sud/Ncstn^tm1.1Sud Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstn^tm1.1Sud mutation (0 available); any Ncstn mutation (36 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased exploration in new environment ( J:234705 )

• mice exhibit increased exploratory behavior in both the open field and elevated plus maze

increased grooming behavior ( J:234705 )

• compulsive grooming in symptomatic mice

• presymptomatic mice show a trend towards excessive grooming

hyperactivity ( J:234705 )

• mice are hyperactive in both the open field and elevated plus maze

• treatment with an acute intraperitoneal injection of a low dose of haloperidol reverses the hyperactivity but does not alter the thigmotaxis in the open field maze

increased stereotypic behavior ( J:234705 )

• mice exhibit trichotillomania

integument

abnormal coat appearance ( J:234705 )

• aged mice exhibit extensive bald patches localized to the nape of the neck and upper back

skin lesions ( J:234705 )

• bald patches progress to full lesions with 100% penetrance by 9 months of age

• lesions are self-inflicted and not caused by social grooming

• lesions are not responsive to topical antibiotic, anti-inflammatory, or antihistamine treatment and mice do not exhibit a difference in response to histamine injection compared to controls

nervous system

decreased myelin sheath thickness ( J:234705 )

• thinner myelin sheaths in the optic nerve, indicating hypomyelination in the optic nerve

• however, myelination in the spinal cord and sciatic nerve is normal

dysmyelination ( J:234705 )

• hypomyelination in the optic nerve

decreased prepulse inhibition ( J:234705 )

• mice are less sensitive to the prepulse and thus show reduced inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:234705

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:105927 )

• double heterozygotes are viable to E18.0 but no live mice are recovered

nervous system

absent oligodendrocytes ( J:105927 )

• oligodendrocytes cannot be detected in mutant embryos examined from E12.5-18

decreased motor neuron number ( J:105927 )

• at E10.0, few motor neurons are detectable in the ventral spinal cord compared to wild-type; this result is consistent from E10.5-14

cellular

absent oligodendrocytes ( J:105927 )

• oligodendrocytes cannot be detected in mutant embryos examined from E12.5-18

Allelic Composition	Chd7^tm1.1Dmm/Chd7^tm1.1Dmm Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7^tm1.1Dmm mutation (1 available); any Chd7 mutation (134 available)
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte number ( J:234565 )

• decrease in the number of MBP+ oligodendrocytes in the spinal cord

• decrease in the number of CC1+ oligodendrocytes and oligodendrocyte lineage cells in the cortices

• number of CC1+ oligodendrocytes increases with age, eventually reaching control levels in the spinal cord

decreased myelin sheath thickness ( J:234565 )

• at P28 in the optic nerve

dysmyelination ( J:234565 )

• decrease in the number of myelinated axons at P14 in the optic nerve

• degree of hypomyelination decreases with age with no difference detected in the spinal cord at P60

cellular

decreased oligodendrocyte number ( J:234565 )

• decrease in the number of MBP+ oligodendrocytes in the spinal cord

• decrease in the number of CC1+ oligodendrocytes and oligodendrocyte lineage cells in the cortices

• number of CC1+ oligodendrocytes increases with age, eventually reaching control levels in the spinal cord

Allelic Composition	Seh1l^tm1Lzha/Seh1l^tm1Lzha Olig1^tm1(cre)Rth/Olig1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (15 available)
Seh1l^tm1Lzha mutation (0 available); any Seh1l mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:276253 )

• mice die during the third postnatal week

behavior/neurological

tremors ( J:276253 )

• mice develop tremors from postnatal week 2

ataxia ( J:276253 )

• mice develop ataxia from postnatal week 2

seizures ( J:276253 )

• mice develop seizures from postnatal week 2

nervous system

seizures ( J:276253 )

• mice develop seizures from postnatal week 2

decreased oligodendrocyte number ( J:276253 )

• reduction of mature oligodendrocytes

• however, oligodendrocyte progenitor cell markers are detected in the spinal cord and brain at P4, P7, and P14 and oligodendrocyte progenitor cell proliferation rates are normal and markers of mature neurons, astrocytes, and microglia are similar to wild-type

abnormal brain development ( J:276253 )

• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects

dysmyelination ( J:276253 )

• optic nerve is translucent indicating a deficiency of myelin formation

• myelinated axons are hardly detectable in the optic nerve, corpus callosum, or spinal cord at P14

cellular

decreased oligodendrocyte number ( J:276253 )

• reduction of mature oligodendrocytes

abnormal cell differentiation ( J:276253 )

• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects

Allelic Composition	Olig1^tm1(cre)Rth/Olig1⁺ Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1^tm1(cre)Rth mutation (1 available); any Olig1 mutation (15 available)
Secisbp2l^tm1.1Qiu mutation (0 available); any Secisbp2l mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte number ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

abnormal oligodendrocyte differentiation ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

• treatment with a T3 analog (GC-1) but not with T4, stimulates oligodendrocyte differentiation

decreased myelin sheath thickness ( J:333465 )

• in the white matter of the spinal cord at P15

homeostasis/metabolism

increased thyroxine level ( J:333465 )

• increased T4 levels in brain and spinal cord lysates

decreased triiodothyronine level ( J:333465 )

• decreased T3 levels in brain and spinal cord lysates

behavior/neurological

tremors ( J:333465 )

• strong trembling in tail suspension assays at P15 and at P45

cellular

decreased oligodendrocyte number ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

abnormal oligodendrocyte differentiation ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

• treatment with a T3 analog (GC-1) but not with T4, stimulates oligodendrocyte differentiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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