All Phenotypes Foxl2<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Foxl2^tm1Tre/Foxl2⁺	involves: 129P2/OlaHsd * Black Swiss * CD-1	MGI:3029670
ht2	Foxl2^{tm1(GFP/cre/ERT2)Pzg}/Foxl2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4947116
ht3	Foxl2^tm4(cre)Tre/Foxl2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4430331
cn4	Foxl2^tm1.1Rthi/Foxl2⁺ Amhr2^tm3(cre)Bhr/Amhr2⁺	B6.Cg-Foxl2^tm1.1Rthi Amhr2^tm3(cre)Bhr	MGI:8250567

Allelic Composition	Foxl2^tm1Tre/Foxl2⁺
Genetic Background	involves: 129P2/OlaHsd * Black Swiss * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2^tm1Tre mutation (0 available); any Foxl2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced female fertility ( J:87737 )

• heterozygous females were subfertile

Allelic Composition	Foxl2^{tm1(GFP/cre/ERT2)Pzg}/Foxl2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2^{tm1(GFP/cre/ERT2)Pzg} mutation (1 available); any Foxl2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:159099 )

• mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities

Allelic Composition	Foxl2^tm4(cre)Tre/Foxl2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2^tm4(cre)Tre mutation (0 available); any Foxl2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:157008 )

N	• mice are fully fertile

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:369668 )

• fewer than the expected numbers of mice are obtained, with a sex imbalance favoring males, with only 8% of progeny being females

• females develop normally into adulthood

neoplasm

increased granulosa cell tumor incidence ( J:369668 )

• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:369668 )

• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

ovary cyst ( J:369668 )

• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

growth/size/body

ovary cyst ( J:369668 )

• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

reproductive system

increased granulosa cell tumor incidence ( J:369668 )

• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

ovary cyst ( J:369668 )

• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
granulosa cell tumor		DOID:2999		J:369668

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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