All Phenotypes Map3k4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map3k4⁺
wild type
MGI:2438230

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Map3k4^tm1Glj/Map3k4⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:3604812
cx2	Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J	B6.Cg-Map3k4^tm1Flv Chr Y^AKR	MGI:4361432
cx3	Gadd45g^tm1Jni/Gadd45g⁺ Map3k4^tm1Flv/Map3k4⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:5461495
cx4	Del(17)T^hp/Map3k4^byg	involves: AKR/J * C3H/HeH * C57BL/6J	MGI:4361425

Allelic Composition	Map3k4^tm1Glj/Map3k4⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4^tm1Glj mutation (2 available); any Map3k4 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:101350 )

• about 25% of heterozygous embryos display neural tube defects

skeleton

abnormal sternum morphology ( J:101350 )

• in heterozygotes with asymmetric attachment of the ribs severe curvature of the sternum is seen

asymmetric sternocostal joints ( J:101350 )

• asymmetric attachment of the ribs to the sternum is seen in 5 - 8% of heterozygotes

decreased rib number ( J:101350 )

• in heterozygotes with asymmetric attachment of the ribs some ribs are absent

abnormal vertebrae morphology ( J:101350 )

embryo

abnormal neural tube morphology ( J:101350 )

• about 25% of heterozygous embryos display neural tube defects

Allelic Composition	Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J
Genetic Background	B6.Cg-Map3k4^tm1Flv Chr Y^AKR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4^tm1Flv mutation (1 available); any Map3k4 mutation (79 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ovotestis development in Map3k4^tm1Flv/Map3k4⁺ X/Sry^AKR/J embryos, characterised by gonadal poles (brackets) lacking markers of testis development and expressing markers of ovary development

reproductive system

small testis ( J:153050 )

• at 11 weeks

ovotestis ( J:153050 )

primary sex reversal ( J:153050 )

• in XY gonads

endocrine/exocrine glands

small testis ( J:153050 )

• at 11 weeks

Allelic Composition	Gadd45g^tm1Jni/Gadd45g⁺ Map3k4^tm1Flv/Map3k4⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45g^tm1Jni mutation (0 available); any Gadd45g mutation (11 available)
Map3k4^tm1Flv mutation (1 available); any Map3k4 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal testis development ( J:191096 )

• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways

reproductive system

abnormal testis development ( J:191096 )

• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways

Allelic Composition	Del(17)T^hp/Map3k4^byg
Genetic Background	involves: AKR/J * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)T^hp mutation (3 available); any Del(17)T^hp mutation (2 available)
Map3k4^byg mutation (1 available); any Map3k4 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

XY embryos doubly heterozygous for Map3k4^byg and Del(17)T^hp exhibit a range of defects of gonad development similar to Map3k4^byg homozygotes

reproductive system

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

primary sex reversal ( J:153050 )

• at E13.5 and E14.5, XY gonads exhibit disruption in cord morphology or gonadal sex reversal

nervous system

abnormal neural tube morphology ( J:153050 )

endocrine/exocrine glands

abnormal testis cord formation ( J:153050 )

• testes exhibit regions lacking clear cord morphology unlike in wild-type mice

embryo

abnormal neural tube morphology ( J:153050 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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