Phenotypes associated with this allele

• Allele Symbol: Mapk1⁺
• Allele Name: wild type
• Allele ID: MGI:2438215
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mapk1^tm1.1Kuta/Mapk1^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	MGI:3759810
ht2	Mapk1^tm2Hed/Mapk1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3687231
ht3	Mapk1^tm1Melo/Mapk1^+	involves: 129S2/SvPas	MGI:3851932
ht4	Mapk1^tm1Melo/Mapk1^+	involves: 129S2/SvPas * C57BL/6	MGI:2683207
ht5	Mapk1^tm1Melo/Mapk1^+	involves: C57BL/6	MGI:3766575
cn6	Mapk1^tm1Melo/Mapk1^+ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0	involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N	MGI:3822161
cx7	Mapk1^tm1Melo/Mapk1^+ Tg(Myh6-Map2k1*)1Jmol/0	involves: 129S2/SvPas * FVB	MGI:3851931
cx8	Mapk1^tm1Melo/Mapk1^+ Tg(Myh7-Ptpn11*Q79R)11Rbns/0	involves: 129S2/SvPas * FVB/N	MGI:3822149

Genotype
MGI:3759810

ht1

• Allelic Composition: Mapk1^tm1.1Kuta/Mapk1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:125594 )

• fewer than expected mice are born

growth/size/body

decreased body size ( J:125594 )

Genotype
MGI:3687231

ht2

• Allelic Composition: Mapk1^tm2Hed/Mapk1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

reproductive system

transmission ratio distortion ( J:113280 )

• transmission of deficient allele decreases with each generation in backcrosses to C57BL/6 such that by F4, there is only one male heterozygote out of 37 offspring

• background sensitivity when an F3 heterozygote is backcrossed to 129/Sv, the mutant allele shows 54% transmission

Genotype
MGI:3851932

ht3

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺
• Genetic Background: involves: 129S2/SvPas

cardiovascular system

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

decreased cardiac muscle contractility ( J:124903 )

• mice show significant reductions in fractional shortening at 4 and 8 weeks after TAC

muscle

decreased cardiac muscle contractility ( J:124903 )

• mice show significant reductions in fractional shortening at 4 and 8 weeks after TAC

growth/size/body

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

Genotype
MGI:2683207

ht4

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

mortality/aging

preweaning lethality, incomplete penetrance ( J:85868 )

• Background Sensitivity: fewer heterozygous pups are obtained than expected by a Mendelian ratio from heterozygous intercrosses on a background involving 129S2/SvPas and C57BL/6; in contrast, the number of heterozygous offspring is similar to what is expected on a background involving CD-1

Genotype
MGI:3766575

ht5

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺
• Genetic Background: involves: C57BL/6

cardiovascular system

decreased cardiac output ( J:127872 )

• after ischemia/reperfusion injury, mice show a decrease in cardiac output compared to wild-type

decreased cardiac muscle contractility ( J:127872 )

• 7 days after ischemia injury, mice have 40% more decrease in ejection fraction compared to wild-type controls and a greater decrease in dP/dtmax

increased myocardial infarct size ( J:127872 )

• after ischemia/reperfusion injury, mice have 30% increase in left ventricular infarct area

muscle

decreased cardiac muscle contractility ( J:127872 )

• 7 days after ischemia injury, mice have 40% more decrease in ejection fraction compared to wild-type controls and a greater decrease in dP/dtmax

increased cardiomyocyte apoptosis ( J:127872 )

• 2 fold more cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury as compared to wild-type controls

homeostasis/metabolism

increased myocardial infarct size ( J:127872 )

• after ischemia/reperfusion injury, mice have 30% increase in left ventricular infarct area

cellular

increased cardiomyocyte apoptosis ( J:127872 )

• 2 fold more cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury as compared to wild-type controls

Genotype
MGI:3822161

cn6

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺; Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142212 )

• all mice died by E14.5

cardiovascular system

increased atrioventricular cushion size ( J:142212 )

double outlet right ventricle ( J:142212 )

• the frequency of double outlet right ventricles is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

ventricular septal defect ( J:142212 )

• the frequency of ventricular septal defects is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

abnormal cardiovascular system physiology ( J:142212 )

• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased while apoptosis rates are decreased compared to in wild-type

liver/biliary system

hepatic necrosis ( J:142212 )

homeostasis/metabolism

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

integument

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

growth/size/body

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

Genotype
MGI:3851931

cx7

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺; Tg(Myh6-Map2k1*)1Jmol/0
• Genetic Background: involves: 129S2/SvPas * FVB

cardiovascular system

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

growth/size/body

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

Genotype
MGI:3822149

cx8

• Allelic Composition: Mapk1^tm1Melo/Mapk1⁺; Tg(Myh7-Ptpn11*Q79R)11Rbns/0
• Genetic Background: involves: 129S2/SvPas * FVB/N

cardiovascular system

cardiovascular system phenotype ( J:123963 )

N • unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, heart weight, ventricular compaction, cardiac cell proliferation and heart function are normal

respiratory system

respiratory system phenotype ( J:123963 )

N • unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, lung weight is normal