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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Robo3+
wild type
MGI:2437943
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Robo3em1(IMPC)H/Robo3+ C57BL/6NTac-Robo3em1(IMPC)H/H MGI:7267081
cx2
 		Robo3tm1Matl/Robo3+
Tg(Atoh1-lacZ)1Jejo/? 		Not Specified MGI:3821857
cx3
 		Lhx2tm1Dra/Lhx2+
Lhx9tm1Dodd/Lhx9tm1Dodd
Robo3tm1Matl/Robo3+ 		Not Specified MGI:3821858


Genotype
MGI:7267081
ht1
Allelic
Composition		 Robo3em1(IMPC)H/Robo3+
Genetic
Background		 C57BL/6NTac-Robo3em1(IMPC)H/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo3em1(IMPC)H mutation (3 available); any Robo3 mutation (76 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

growth/size/body
increased heart weight ( J:211773 )
IMPC - HAR

homeostasis/metabolism

vision/eye




Genotype
MGI:3821857
cx2
Allelic
Composition		 Robo3tm1Matl/Robo3+
Tg(Atoh1-lacZ)1Jejo/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo3tm1Matl mutation (1 available); any Robo3 mutation (76 available)
Tg(Atoh1-lacZ)1Jejo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dorsal interneuron 1 morphology ( J:142117 )
• some dl1 neurons migrate ectopically to a more ventral position
• a modest 11% reduction in midline cross over of axons from dl1c neurons
• project instead along the ipsilateral ventral funiculus




Genotype
MGI:3821858
cx3
Allelic
Composition		 Lhx2tm1Dra/Lhx2+
Lhx9tm1Dodd/Lhx9tm1Dodd
Robo3tm1Matl/Robo3+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1Dra mutation (0 available); any Lhx2 mutation (11 available)
Lhx9tm1Dodd mutation (0 available); any Lhx9 mutation (30 available)
Robo3tm1Matl mutation (1 available); any Robo3 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dorsal interneuron 1 morphology ( J:142117 )
• a 61% reduction in midline cross over of axons from dl1c neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory