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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Uri1+
wild type
MGI:2437915
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Uri1tm1.1Ndj/Uri1+
Albtm1(cre/ERT2)Mtz/Alb+ 		B6.Cg-Albtm1(cre/ERT2)Mtz Uri1tm1.1Ndj MGI:6378450


Genotype
MGI:6378450
cn1
Allelic
Composition		 Uri1tm1.1Ndj/Uri1+
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background		 B6.Cg-Albtm1(cre/ERT2)Mtz Uri1tm1.1Ndj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (95 available)
Uri1tm1.1Ndj mutation (0 available); any Uri1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:217463 )
• NAD+ levels are increased in tamoxifen-treated livers
decreased incidence of tumors by chemical induction ( J:217463 )
• tamoxifen-treated mice treated with diethylnitrosamine (DEN) do not show tumors at 24 weeks of age as seen in 60% of control mice and show normal alanine transaminase levels
decreased susceptibility to injury ( J:217463 )
• tamoxifien-treated mice supplied with a liver damage-inducing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC)-supplemented diet present less liver damage and fibrosis

neoplasm
decreased incidence of tumors by chemical induction ( J:217463 )
• tamoxifen-treated mice treated with diethylnitrosamine (DEN) do not show tumors at 24 weeks of age as seen in 60% of control mice and show normal alanine transaminase levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory