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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sema3a+
wild type
MGI:2437856
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sema3atm1Mcf/Sema3a+ involves: 129S4/SvJae MGI:3770683
cx2
 		Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3a+ 		involves: 129S4/SvJae * C57BL/6 MGI:3770681


Genotype
MGI:3770683
ht1
Allelic
Composition		 Sema3atm1Mcf/Sema3a+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3atm1Mcf mutation (0 available); any Sema3a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:127639 )
• at E12.5, peripheral nerves are not as severely stunted as in Ngfrtm1Jae Sema3atm1Mcf homozygotes
• at E12.5, neuron growth is increased 1.19-fold in hindlimbs, 1.25-fold in forelimbs and 1.19-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes

cellular
abnormal neuron differentiation ( J:127639 )
• at E12.5, peripheral nerves are not as severely stunted as in Ngfrtm1Jae Sema3atm1Mcf homozygotes
• at E12.5, neuron growth is increased 1.19-fold in hindlimbs, 1.25-fold in forelimbs and 1.19-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes




Genotype
MGI:3770681
cx2
Allelic
Composition		 Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3a+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (3 available); any Ngfr mutation (31 available)
Sema3atm1Mcf mutation (0 available); any Sema3a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:127639 )
N
• at E12.5, mice exhibit normal neuron growth that is increased 3-fold in hindlimbs, 2.7-fold in forelimbs and 4.4-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory