All Phenotypes Mapkapk5<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapkapk5⁺
wild type
MGI:2437434

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mapkapk5^tm1Pqs/Mapkapk5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3723514
cx2	Mapkapk5^tm1Pqs/Mapkapk5⁺ Tg(SV40-NRAS*G12D)1Sco/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3757992

Allelic Composition	Mapkapk5^tm1Pqs/Mapkapk5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5^tm1Pqs mutation (0 available); any Mapkapk5 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:117893 )

• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5^tm1Pqs homozygotes

• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment

• only one papilloma progressed to malignant carcinoma 5 months after detection

• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection

• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium

• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors

• however, untreated mice are healthy and tumor-free for at least 2 years

cellular

delayed cellular replicative senescence ( J:117893 )

• mouse skin fibroblast cells derived from mice express less ras-induced senescence markers than wild-type DMBA-induced tumors

integument

increased skin papilloma incidence ( J:117893 )

• 12 of 30 mice developed skin papillomas following treatment with DMBA compared to only 1 of 12 wild-type mice and 7 of 13 in Mapkapk5^tm1Pqs homozygotes

• however, mice do not show altered susceptibility in terms of incidence or latency to skin cancer following TPA and DMBA treatment

• only one papilloma progressed to malignant carcinoma 5 months after detection

• DMBA-induced tumors grow slowly but progressively and usually reach a size of more than 10mm in diameter within 2-3 weeks after initial detection compared to tumors in wild-type mice that seem to be dormant and remain at about 2 to 3 mm in diameter after 2 months from initial detection

• DMBA-induced tumors also had more complicated structures with much thinner and more folded layers of squamous epithelium

• DMBA-induced tumors express less senescence markers than wild-type DMBA-induced tumors

• however, untreated mice are healthy and tumor-free for at least 2 years

Allelic Composition	Mapkapk5^tm1Pqs/Mapkapk5⁺ Tg(SV40-NRAS*G12D)1Sco/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk5^tm1Pqs mutation (0 available); any Mapkapk5 mutation (31 available)
Tg(SV40-NRAS*G12D)1Sco mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:117893 )

• lymphomagenesis is enhanced relative to in Tg(SV40-NRAS*G12D)1Sco mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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