Analysis Tools|
Allele Symbol Allele Name Allele ID |
Magoh+ wild type MGI:2437284 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• premature death occurs before weaning in some animals
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• before weaning with incomplete penetrance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• premature death occurs before weaning in some animals
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• before weaning with incomplete penetrance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E16.5, cortical thickness is ~50% that of wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls
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• premature death occurs before weaning in some animals
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• before weaning with incomplete penetrance
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• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls
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• 33% smaller than control littermates
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• most ectopically produced neurons undergo apoptosis
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• brains exhibit extensive apoptosis in the cortex at E14.5
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• ectopic and precocious neurogenesis resulting in expanded calretinin-positive cells and ectopically produced Cajal Retzius cells in cortex
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• at E18.5 the cortical layers were thinner and disorganized
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• adult brain weighed significantly less than those of control littermates
(J:159625)
• present prenatally starting between E12.5 and E18.5
(J:159625)
• at E18.5, brain size is disproportionally reduced by 30% relative to body size
(J:240595)
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• forebrain size is significantly reduced at E18.5
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• neocortex size is disproportionally decreased at E13.5
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• intermediate neural progenitors in developing cortex was markedly reduced resulting in the smaller number of neurons in E18.5 brains
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• brains show ectopic neuron differentiation at E12.5
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• abnormal orientation of the neural stem cell mitotic division plane during cortex development
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• most ectopically produced neurons undergo apoptosis
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• brains exhibit extensive apoptosis in the cortex at E14.5
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• ectopic and precocious neurogenesis resulting in expanded calretinin-positive cells and ectopically produced Cajal Retzius cells in cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• heterozygotes are viable, unlike mice heterozygous for the MagohMos2 allele which show partial postnatal lethality on a C57BL/6J background
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• heterozygotes display smaller brain size at E16.5
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• at E16.5, cortical thickness is significantly reduced relative to wild-type controls, although to a slightly lesser extent than in mice heterozygous for the MagohMos2 allele
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• adult heterozygotes exhibit white belly spots
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• adult heterozygotes exhibit ventral and dorsal hypopigmentation, similar to adult mice heterozygous for the MagohMos2 allele
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• adult heterozygotes exhibit white belly spots
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P12, mutant mice exhibit significantly smaller brains than heterozygous Emx1tm1(cre)Krj control mice
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• at E16.5, cortical thickness is significantly reduced relative to wild-type controls, but thicker than in mice heterozygous for the MagohMos2 allele (likely due to a contribution of ventrally derived neurons which migrate into the dorsal telencephalon, but are not targeted by Emx1-Cre)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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