Analysis Tools
endocrine/exocrine glands
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• heterozygous null ovaries displayed normal endocrine function
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reproductive system
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• heterozygous null mice showed an ovarian phenotype that was intermediate between wild-type and homozygous null mice
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• ovarian sections from superovulated immature heterozygotes revealed luteinizing follicles with occasional hemorrhagic cysts; this phenotype was more pronounced in mature mice but to an intermediate extent relative to homozygous null mice
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• superovulation of heterozygous mice resulted in a failure of approximately 50% of the luteinizing follicles to release the oocyte
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