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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hk2+
wild type
MGI:2437200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Hk2tm1Laak/Hk2+ involves: 129P2/OlaHsd * BALB/c * DBA/2 MGI:3625100
cn2
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2+
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N MGI:5571384


Genotype
MGI:3625100
ht1
Allelic
Composition
Hk2tm1Laak/Hk2+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hk2tm1Laak mutation (1 available); any Hk2 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at weaning, heterozygous male mice produced by the first backcross to BALB/c * DBA/2 weigh less than wild-type littermates, but by the third backcross generation, there is no significant weight difference

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus 2 DOID:0110741 OMIM:125852
J:56644




Genotype
MGI:5571384
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2+
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Hk2tm1.1Uku mutation (1 available); any Hk2 mutation (60 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by P20

neoplasm

nervous system





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory