Phenotypes associated with this allele

• Allele Symbol: Fzd9⁺
• Allele Name: wild type
• Allele ID: MGI:2437134
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fzd9^tm1Uta/Fzd9^+	involves: 129X1/SvJ	MGI:4946081
ht2	Fzd9^tm1Sjp/Fzd9^+	involves: C57BL/6J	MGI:3586705

Genotype
MGI:4946081

ht1

• Allelic Composition: Fzd9^tm1Uta/Fzd9⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone mineral density ( J:169924 )

• osteopenia

decreased trabecular bone volume ( J:169924 )

decreased compact bone thickness ( J:169924 )

• reduction in cortical thickness of femurs

decreased osteoblast cell number ( J:169924 )

abnormal bone ossification ( J:169924 )

• decrease in bone rate formation

decreased bone strength ( J:169924 )

• vertebral bodies and femora exhibit decreased biomechanical competence

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:169924

Genotype
MGI:3586705

ht2

• Allelic Composition: Fzd9^tm1Sjp/Fzd9⁺
• Genetic Background: involves: C57BL/6J

nervous system

abnormal forebrain development ( J:99893 )

• at E14.5, there is a slight increase, less than that in homozygotes, in M-phase precursor cells in the medial cortical wall compared to wild-type mice

• at E14.5, the number of apoptotic cells in the dentate analage is less than in homozygotes but still increased compared to wild-type mice

abnormal dentate gyrus morphology ( J:99893 )

• a decrease in the number of dentate granule cells and an increase in the hilar mossy cell number, intermediate to that detected in homozygous mutants, are seen