About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd40+
wild type
MGI:2437057
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd40tm1Kik/Cd40+
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:6360064


Genotype
MGI:6360064
cn1
Allelic
Composition		 Cd40tm1Kik/Cd40+
Mir146tm1.1Lfl/Mir146tm1.1Lfl
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (11 available); any Cd40 mutation (42 available)
Mir146tm1.1Lfl mutation (1 available); any Mir146 mutation (14 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:266124 )
N
• mice exhibit a restoration of normal IgG1 levels in B cells compared with Mir146tm1.1Tmmc Tg(Cr2-cre)3Cgn mice
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells in mixed bone marrow chimeras

hematopoietic system
increased T follicular helper cell number ( J:266124 )
• following immunization with sheep red blood cells in mixed bone marrow chimeras




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory