Phenotypes associated with this allele

• Allele Symbol: Map1b⁺
• Allele Name: wild type
• Allele ID: MGI:2436787
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Map1b^tm1Rak/Map1b^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3848514
cx2	Kif21a^tm1.1Ece/Kif21a^+ Map1b^tm1Prop/Map1b^+ Tg(Isl1-EGFP*)1Slp/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6	MGI:6241441

Genotype
MGI:3848514

ht1

• Allelic Composition: Map1b^tm1Rak/Map1b⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:31721 )

• mice that develop hindlimb paralysis due to starvation and dehydration

behavior/neurological

lethargy ( J:31721 )

• in mice with defects in both ocular orbs

tremors ( J:31721 )

• mice with defects in both ocular orbs exhibit severe spastic tremors in the hindlimbs

ataxia ( J:31721 )

• mice with defects in both ocular orbs exhibit an ataxic gait

abnormal gait ( J:31721 )

• mice with defects in both ocular orbs exhibit an ataxic gait

hindlimb paralysis ( J:31721 )

• in some mice

nervous system

abnormal hippocampus morphology ( J:31721 )

• the hippocampus lacks 6D4 staining

abnormal olfactory bulb morphology ( J:31721 )

• enlarged

abnormal cerebellum morphology ( J:31721 )

• some mice exhibit abnormal cerebellum shape and size with an attenuated, flattened cerebellar hemisphere and vermis compared with wild-type mice

abnormal Purkinje cell morphology ( J:31721 )

• Purkinje cells lose their flask-shaped appearance and appear flattened

abnormal Purkinje cell dendrite morphology ( J:31721 )

• Purkinje cells are attenuated with truncated dendritic processes and decreased branching compared with wild-type cells

vision/eye

abnormal eye morphology ( J:31721 )

• 20% of mice exhibit gross deformities of the one or both ocular orbs compared with wild-type mice

abnormal eye development ( J:31721 )

• eyes are underdeveloped

disorganized retina inner nuclear layer ( J:31721 )

disorganized retina outer nuclear layer ( J:31721 )

abnormal retina outer plexiform layer morphology ( J:31721 )

• the demarcation of the external plexiform layer are absent

decreased visual acuity ( J:31721 )

• mice with defects in both ocular orbs fail to respond to visual threats

growth/size/body

decreased body size ( J:31721 )

• at 5 months of age

decreased body weight ( J:31721 )

• mice weight 10-50% less than controls

limbs/digits/tail

abnormal hindlimb morphology ( J:31721 )

• at 5 months, mice exhibit splayed hindlimbs unlike wild-type mice

Genotype
MGI:6241441

cx2

• Allelic Composition: Kif21a^tm1.1Ece/Kif21a⁺; Map1b^tm1Prop/Map1b⁺; Tg(Isl1-EGFP*)1Slp/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6

nervous system

abnormal abducens nerve morphology ( J:213171 )

• approximately 90% penetrance of abducens nerve hypoplasia

abnormal oculomotor nerve morphology ( J:213171 )

• oculomotor nerve superior branch axons terminate prematurely within a bulb with a penetrance of 90%