All Phenotypes Prmt1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prmt1⁺
wild type
MGI:2436610

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prmt1^{tm1a(EUCOMM)Wtsi}/Prmt1⁺	B6JTyr;B6N-Prmt1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5781707
cn2	Prmt1^{tm1c(EUCOMM)Wtsi}/Prmt1⁺ Rb1^tm3Tyj/Rb1^tm3Tyj Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1	MGI:7486124

Allelic Composition	Prmt1^{tm1a(EUCOMM)Wtsi}/Prmt1⁺
Genetic Background	B6JTyr;B6N-Prmt1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0070_1_B01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1^{tm1a(EUCOMM)Wtsi} mutation (3 available); any Prmt1 mutation (35 available)

Data Sources

IMPC Data for Prmt1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:175295 )

IMPC - WTSI

Allelic Composition	Prmt1^{tm1c(EUCOMM)Wtsi}/Prmt1⁺ Rb1^tm3Tyj/Rb1^tm3Tyj Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1^{tm1c(EUCOMM)Wtsi} mutation (2 available); any Prmt1 mutation (35 available)
Rb1^tm3Tyj mutation (12 available); any Rb1 mutation (117 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:245660 )

• mice begin to die at ~100 days of age and all die by around 200 days of age, with a median survival similar to that of mutant mice homozygous for the wild-type Prmt1 allele

neoplasm

increased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age

skeleton

increased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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