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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr7+
wild type
MGI:2436519
Summary 3 genotypes


Genotype
MGI:7284974
ht1
Allelic
Composition		 Tlr7em2Anu/Tlr7+
Genetic
Background		 C57BL/6NCrl-Tlr7em2Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7em2Anu mutation (1 available); any Tlr7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:324448 )
• mice show decreased survival

growth/size/body
enlarged spleen ( J:324448 )
• splenomegaly with increased cellularity is seen in 12-week-old mice
spleen hyperplasia ( J:324448 )
• 12-week-old mice show increased spleen cellularity

immune system
enlarged spleen ( J:324448 )
• splenomegaly with increased cellularity is seen in 12-week-old mice
spleen hyperplasia ( J:324448 )
• 12-week-old mice show increased spleen cellularity
increased B cell number ( J:324448 )
• spleen shows reduced T:B cell ratio with an increase in in total B cells
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)
decreased marginal zone B cell number ( J:324448 )
• percentage of splenic marginal zone B cells is decreased, but the total numbers are not decreased
increased spleen germinal center number ( J:324448 )
• spleen shows spontaneous germinal centers
abnormal plasmacytoid dendritic cell physiology ( J:324448 )
• plasmacytoid dendritic cells appear to be activated with increased MHC-II and reduced siglec-H expression
increased autoantibody level ( J:324448 )
• mice develop antibodies to the TLR7 ligands ssRNA and Smith protein and ribonucleoprotein (RNP)
increased anti-nuclear antigen antibody level ( J:324448 )
• ANAs are detected from 6 weeks of age in females
increased anti-double stranded DNA antibody level ( J:324448 )
• 60% of mice at 6 months of age show dsDNA antibodies compared to 20% of controls
increased anti-single stranded DNA antibody level ( J:324448 )
• mice show increased autoantibodies to ssDNA at 6 weeks but not 4 weeks of age

hematopoietic system
enlarged spleen ( J:324448 )
• splenomegaly with increased cellularity is seen in 12-week-old mice
spleen hyperplasia ( J:324448 )
• 12-week-old mice show increased spleen cellularity
increased B cell number ( J:324448 )
• spleen shows reduced T:B cell ratio with an increase in in total B cells
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
decreased marginal zone B cell number ( J:324448 )
• percentage of splenic marginal zone B cells is decreased, but the total numbers are not decreased
increased spleen germinal center number ( J:324448 )
• spleen shows spontaneous germinal centers

homeostasis/metabolism

renal/urinary system
expanded mesangial matrix ( J:324448 )
• expanded mesangial matrix with electron-dense deposits and increased mesangial cellularity
renal glomerular immunoglobulin deposits ( J:324448 )
• immunoglobulin deposits in the kidneys




Genotype
MGI:4837539
cx2
Allelic
Composition		 Tlr8/Tlr7tm1Vlcg/Tlr7+
Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic
Background		 B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr8 mutation (9 available)
Tlr8/Tlr7tm1Vlcg mutation (0 available); any Tlr7 mutation (23 available)
Tlr8tm1Vlcg mutation (0 available); any Tlr8 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes
decreased anti-insulin autoantibody level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes

hematopoietic system
abnormal spleen marginal zone morphology ( J:165267 )
• mice exhibit an intermediate marginal zone phenotype compared with Tlr8tm1Vlcg and double homozygotes
decreased marginal zone B cell number ( J:165267 )
• 2 times lower than in double homozygotes
increased marginal zone B cell number ( J:165267 )
• 2 times higher than in Tlr8tm1Vlcg homozygotes
decreased IgG level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgG level ( J:165267 )
• compared with double homozygotes
decreased IgM level ( J:165267 )
• compared with Tlr8tm1Vlcg homozygotes
increased IgM level ( J:165267 )
• compared with double homozygotes




Genotype
MGI:7284994
cx3
Allelic
Composition		 Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+
Genetic
Background		 C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2bem1Anu mutation (0 available); any Rnaseh2b mutation (43 available)
Tlr7em2Anu mutation (1 available); any Tlr7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:324448 )
• mice show a similar phenotype seen in female heterozygous Tlr7em2Anu mice with no exacerbation of the cellular or serological phenotypes seen in these mice except for a mild enhancement in the expression of type I IFN signature genes
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)
increased autoantibody level ( J:324448 )
• mice develop autoantibodies to the TLR7 ligands ssRNA and Smith protein ribonucleoprotein (RNP) and DNA

hematopoietic system
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory