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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Klb+
wild type
MGI:2436338
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Klbem1(IMPC)J/Klb+ C57BL/6NJ-Klbem1(IMPC)J/Mmjax MGI:6696792
cx2
Klbtm1.2Sakl/Klb+
Tg(Apoe-Fgf21)1Sakl/0
involves: 129 * 129S4/SvJaeSor * C57BL/6 MGI:5446169


Genotype
MGI:6696792
ht1
Allelic
Composition
Klbem1(IMPC)J/Klb+
Genetic
Background
C57BL/6NJ-Klbem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klbem1(IMPC)J mutation (2 available); any Klb mutation (60 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological




Genotype
MGI:5446169
cx2
Allelic
Composition
Klbtm1.2Sakl/Klb+
Tg(Apoe-Fgf21)1Sakl/0
Genetic
Background
involves: 129 * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klbtm1.2Sakl mutation (0 available); any Klb mutation (60 available)
Tg(Apoe-Fgf21)1Sakl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet

skeleton
• compared with Klbtm1.2Sakl heterozygotes

adipose tissue
• in mice fed standard chow or a high fat diet compared with Klbtm1.2Sakl heterozygotes

growth/size/body
• in mice fed standard chow or a high fat diet compared with Klbtm1.2Sakl heterozygotes
• compared with Klbtm1.2Sakl heterozygotes
• in mice fed a high fat diet

behavior/neurological
• compared with Klbtm1.2Sakl heterozygotes

liver/biliary system
• in mice fed a high fat diet
• in mice fed a high fat diet
• in mice fed a high fat diet
• mice fed a high fat diet do not develop a pale liver and have less lipid droplets compared to Klbtm1.2Sakl heterozygotes

limbs/digits/tail
• compared with Klbtm1.2Sakl heterozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory