All Phenotypes Lep<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lep⁺
wild type
MGI:2436280

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lep^ob/Lep⁺	involves: 129X1/SvJ * C57BL/6	MGI:3694011
ht2	Lep^ob/Lep⁺	involves: C57BL/6J	MGI:3774858
cn3	Adrb2^tm1Kry/Adrb2⁺ Lep^ob/Lep⁺ Tg(Col1a1-cre)1Kry/0	involves: C57BL/6 * C57BL/10J * FVB	MGI:3837367
cx4	Lep^ob/Lep⁺ Npy4r^tm1.1Hhz/Npy4r^tm1.1Hhz	involves: 129X1/SvJ * C57BL/6	MGI:3694009
cx5	Lep^ob/Lep⁺ Tg(Apoe-Lepr)1Kry/0	involves: C57BL/6J	MGI:3039502

Allelic Composition	Lep^ob/Lep⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased liver weight ( J:76479 )

• mice show significant increase in relative and absolute hepatic weight compared to wild-type; otherwise, no differences from wild-type are noted

growth/size/body

increased liver weight ( J:76479 )

• mice show significant increase in relative and absolute hepatic weight compared to wild-type; otherwise, no differences from wild-type are noted

Allelic Composition	Lep^ob/Lep⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:60001 )

• increased bone mass even on a low fat diet to delay obesity

Allelic Composition	Adrb2^tm1Kry/Adrb2⁺ Lep^ob/Lep⁺ Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: C57BL/6 * C57BL/10J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb2^tm1Kry mutation (0 available); any Adrb2 mutation (33 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:145998 )

• mice exhibit postprandial low blood glucose levels compared to in wild-type mice

increased circulating insulin level ( J:145998 )

Allelic Composition	Lep^ob/Lep⁺ Npy4r^tm1.1Hhz/Npy4r^tm1.1Hhz
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Npy4r^tm1.1Hhz mutation (0 available); any Npy4r mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:76479 )

• males have a tendency toward increased body weight compared to controls

adipose tissue

increased white adipose tissue amount ( J:76479 )

• WAT mass is increased compared to control Lep^ob heterozygotes

Allelic Composition	Lep^ob/Lep⁺ Tg(Apoe-Lepr)1Kry/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Tg(Apoe-Lepr)1Kry mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:88655 )

• mutants have significantly heavier fat pads compared to non-transgenic littermates

skeleton

increased bone mass ( J:88655 )

• mutants have significantly increased bone mass compared to non-transgenic littermates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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