Phenotypes associated with this allele

• Allele Symbol: Dclre1a⁺
• Allele Name: wild type
• Allele ID: MGI:2436199
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dclre1a^tm1Rleg/Dclre1a^+	involves: 129S7/SvEvBrd	MGI:4941810
cx2	Dclre1a^tm1Rleg/Dclre1a^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:4941812

Genotype
MGI:4941810

ht1

• Allelic Composition: Dclre1a^tm1Rleg/Dclre1a⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:102381 )

• decreased survival compared to wild- type littermates over a period of 24 months; males showed a reduction in survival compared to females

neoplasm

increased tumor incidence ( J:102381 )

• heterozygous mice started to develop tumors from the age of 16 months

increased lymphoma incidence ( J:102381 )

• 4/16 heterozygous mice (25%) developed lymphoma (systemic or lung, mandibular, or adrenal lymph node)

increased histiocytic sarcoma incidence ( J:102381 )

• 1 of 16 mice (6.3%) developed histiocytic sarcoma

decreased tumor latency ( J:102381 )

• accelerated tumorigenesis in heterozygous females

Genotype
MGI:4941812

cx2

• Allelic Composition: Dclre1a^tm1Rleg/Dclre1a⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

neoplasm

increased sarcoma incidence ( J:102381 )

• sarcomas were observed