About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dvl3+
wild type
MGI:2436128
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444710
cx2
 		Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444711
cx3
 		Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+ 		involves: 129S6/SvEvTac * A * Black Swiss MGI:3831924
cx4
 		Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3831929
cx5
 		Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3831932


Genotype
MGI:5444710
cx1
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=14) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444711
cx2
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 83% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:3831924
cx3
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S6/SvEvTac * A * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:142392 )
• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
incomplete rostral neuropore closure ( J:142392 )
• some mice develop defects in rostral neural tube closure
craniorachischisis ( J:142392 )
• in 5 of 22 mice
decreased cochlear outer hair cell number ( J:142392 )
• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
increased cochlear hair cell number ( J:142392 )
• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
exencephaly ( J:142392 )
• in 2 of 22 mice

cardiovascular system
cardiovascular system phenotype ( J:142392 )
N
• hearts develop normally

hearing/vestibular/ear
decreased cochlear outer hair cell number ( J:142392 )
• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
increased cochlear hair cell number ( J:142392 )
• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
inner ear hypoplasia ( J:142392 )
• in mice with neural tube defects

embryo
abnormal neural tube morphology ( J:142392 )
• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
incomplete rostral neuropore closure ( J:142392 )
• some mice develop defects in rostral neural tube closure
craniorachischisis ( J:142392 )
• in 5 of 22 mice




Genotype
MGI:3831929
cx4
Allelic
Composition		 Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

embryo

nervous system

homeostasis/metabolism




Genotype
MGI:3831932
cx5
Allelic
Composition		 Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:142392 )
• at E18.5, 11 of 28 mice exhibit conotruncal defects
persistent truncus arteriosus ( J:142392 )
• in 1 of 11 mice
double outlet right ventricle ( J:142392 )
• in 9 of 11 mice

hearing/vestibular/ear

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory