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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dvl3+
wild type
MGI:2436128
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444710
cx2
 		Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444711
cx3
 		Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+ 		involves: 129S6/SvEvTac * A * Black Swiss MGI:3831924
cx4
 		Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3831929
cx5
 		Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3831932


Genotype
MGI:5444710
cx1
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=14) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444711
cx2
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 83% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:3831924
cx3
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S6/SvEvTac * A * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:142392 )
• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
incomplete rostral neuropore closure ( J:142392 )
• some mice develop defects in rostral neural tube closure
craniorachischisis ( J:142392 )
• in 5 of 22 mice
decreased cochlear outer hair cell number ( J:142392 )
• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
increased cochlear hair cell number ( J:142392 )
• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
exencephaly ( J:142392 )
• in 2 of 22 mice

cardiovascular system
cardiovascular system phenotype ( J:142392 )
N
• hearts develop normally

hearing/vestibular/ear
decreased cochlear outer hair cell number ( J:142392 )
• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length
increased cochlear hair cell number ( J:142392 )
• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts
• stereociliary bundles in apical regions are rotated compared to in wild-type mice
inner ear hypoplasia ( J:142392 )
• in mice with neural tube defects

embryo
abnormal neural tube morphology ( J:142392 )
• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly
incomplete rostral neuropore closure ( J:142392 )
• some mice develop defects in rostral neural tube closure
craniorachischisis ( J:142392 )
• in 5 of 22 mice




Genotype
MGI:3831929
cx4
Allelic
Composition		 Dvl2tm1Awb/Dvl2tm1Awb
Dvl3tm1Awb/Dvl3+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

embryo

nervous system

homeostasis/metabolism




Genotype
MGI:3831932
cx5
Allelic
Composition		 Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:142392 )
• at E18.5, 11 of 28 mice exhibit conotruncal defects
persistent truncus arteriosus ( J:142392 )
• in 1 of 11 mice
double outlet right ventricle ( J:142392 )
• in 9 of 11 mice

hearing/vestibular/ear

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory