All Phenotypes Atf4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atf4⁺
wild type
MGI:2436106

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atf4^tm1(KOMP)Mbp/Atf4⁺	C57BL/6NCrl-Atf4^tm1(KOMP)Mbp/MbpMmucd	MGI:7414783
cx2	Atf4^tm1Tow/Atf4⁺ Ptprv^tm1Asmi/Ptprv⁺	either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)	MGI:4360508
cx3	Atf4^tm1Tow/Atf4⁺ Satb2^tm1Rug/Satb2⁺	either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)	MGI:3696661

Allelic Composition	Atf4^tm1(KOMP)Mbp/Atf4⁺
Genetic Background	C57BL/6NCrl-Atf4^tm1(KOMP)Mbp/MbpMmucd
Cell Lines	DEPD00549_2_B06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1(KOMP)Mbp mutation (1 available); any Atf4 mutation (23 available)

Data Sources

IMPC Data for Atf4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased monocyte cell number ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

IMPC - UCD

increased circulating aspartate transaminase level ( J:211773 )

IMPC - UCD

immune system

decreased monocyte cell number ( J:211773 )

IMPC - UCD

Allelic Composition	Atf4^tm1Tow/Atf4⁺ Ptprv^tm1Asmi/Ptprv⁺
Genetic Background	either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1Tow mutation (1 available); any Atf4 mutation (23 available)
Ptprv^tm1Asmi mutation (0 available); any Ptprv mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:152695 )

increased circulating insulin level ( J:152695 )

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

cellular

increased pancreatic beta cell proliferation ( J:152695 )

• beta cell proliferation is increased compared to in wild-type mice

Allelic Composition	Atf4^tm1Tow/Atf4⁺ Satb2^tm1Rug/Satb2⁺
Genetic Background	either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4^tm1Tow mutation (1 available); any Atf4 mutation (23 available)
Satb2^tm1Rug mutation (0 available); any Satb2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:115876 )

decreased bone volume ( J:115876 )

• bone volume/total volume is reduced from 15.5% in wild-type to 8.53% in mutants

decreased bone trabecula number ( J:115876 )

• trabecular numbers/mm are reduced from 4.54 in wild-type to 2.48 in mutants

decreased bone ossification ( J:115876 )

• display a marked reduction of bone formation at E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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