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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf11b+
wild type
MGI:2435754
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tnfrsf11btm1Wss/Tnfrsf11b+ either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) MGI:3849485
cx2
 		Klkl/Klkl
Tnfrsf11btm1Khs/Tnfrsf11b+ 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:3653639


Genotype
MGI:3849485
ht1
Allelic
Composition		 Tnfrsf11btm1Wss/Tnfrsf11b+
Genetic
Background		 either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf11btm1Wss mutation (0 available); any Tnfrsf11b mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone mineral density ( J:47602 )
• mice have about less bone density by six months of age (487.6 vs. 521.2 mg/cm3 in controls)




Genotype
MGI:3653639
cx2
Allelic
Composition		 Klkl/Klkl
Tnfrsf11btm1Khs/Tnfrsf11b+
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klkl mutation (2 available); any Kl mutation (51 available)
Tnfrsf11btm1Khs mutation (0 available); any Tnfrsf11b mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
short femur ( J:80503 )
• femur length is shorter than in mice homozygous for Kl only; however osteopetrotic changes in the bone are reduced and the number of osteoclasts is similar to wild-type

growth/size/body
decreased body weight ( J:80503 )
• similar to mice homozygous for Kl mutation only

immune system
decreased B cell number ( J:80503 )
• similar to mice homozygous for Kl mutation only

limbs/digits/tail
short femur ( J:80503 )
• femur length is shorter than in mice homozygous for Kl only; however osteopetrotic changes in the bone are reduced and the number of osteoclasts is similar to wild-type

hematopoietic system
decreased B cell number ( J:80503 )
• similar to mice homozygous for Kl mutation only




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory