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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx3+
wild type
MGI:2435716
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tbx3em1(IMPC)Mbp/Tbx3+ C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd MGI:7415108
ht2
 		Tbx3tm1Pa/Tbx3+ either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac) MGI:2655217
ht3
 		Tbx3tm2Moon/Tbx3+ involves: 129 * C57BL/6 MGI:5538602
ht4
 		Tbx3tm1.1Moon/Tbx3+ involves: 129 * C57BL/6 * SJL MGI:5538601
ht5
 		Tbx3tm1.1(cre)Vmc/Tbx3+ involves: 129P2/OlaHsd * FVB/N * NMRI MGI:4418057
cx6
 		Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Tbx3tm1.1(cre)Vmc/Tbx3+ 		involves: 129P2/OlaHsd * FVB/N * NMRI MGI:4418052
cx7
 		Tbx2tm1.1(cre)Vmc/Tbx2+
Tbx3tm1.1(cre)Vmc/Tbx3+ 		involves: 129P2/OlaHsd * FVB/N * NMRI MGI:4418053


Genotype
MGI:7415108
ht1
Allelic
Composition		 Tbx3em1(IMPC)Mbp/Tbx3+
Genetic
Background		 C57BL/6NCrl-Tbx3em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3em1(IMPC)Mbp mutation (1 available); any Tbx3 mutation (51 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system
eye hemorrhage ( J:211773 )
IMPC - UCD

homeostasis/metabolism

immune system

vision/eye
eye hemorrhage ( J:211773 )
IMPC - UCD
microphthalmia ( J:211773 )
IMPC - UCD




Genotype
MGI:2655217
ht2
Allelic
Composition		 Tbx3tm1Pa/Tbx3+
Genetic
Background		 either: (involves: 129 * 129S1/Sv * 129X1/SvJ) or (involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6NTac)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1Pa mutation (1 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal clitoris morphology ( J:82458 )
• all adult heterozyotes exhibit a small ventral split in the glans clitoris, resulting in a distal bifurcation of the prepuce
abnormal vagina orifice morphology ( J:82458 )
• 9 of 85 adult heterozygotes display a failure of vaginal opening




Genotype
MGI:5538602
ht3
Allelic
Composition		 Tbx3tm2Moon/Tbx3+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm2Moon mutation (0 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
irregular heartbeat ( J:179977 )
• atrial arrhythmia in embryos




Genotype
MGI:5538601
ht4
Allelic
Composition		 Tbx3tm1.1Moon/Tbx3+
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1.1Moon mutation (0 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

cardiovascular system
irregular heartbeat ( J:179977 )
• atrial arrhythmia in embryos




Genotype
MGI:4418057
ht5
Allelic
Composition		 Tbx3tm1.1(cre)Vmc/Tbx3+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm1.1(cre)Vmc mutation (0 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:154920 )
• mice are phenotypically normal on this outbred background




Genotype
MGI:4418052
cx6
Allelic
Composition		 Tbx2tm1.1(cre)Vmc/Tbx2tm1.1(cre)Vmc
Tbx3tm1.1(cre)Vmc/Tbx3+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx2tm1.1(cre)Vmc mutation (0 available); any Tbx2 mutation (29 available)
Tbx3tm1.1(cre)Vmc mutation (0 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:154920 )
• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure




Genotype
MGI:4418053
cx7
Allelic
Composition		 Tbx2tm1.1(cre)Vmc/Tbx2+
Tbx3tm1.1(cre)Vmc/Tbx3+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx2tm1.1(cre)Vmc mutation (0 available); any Tbx2 mutation (29 available)
Tbx3tm1.1(cre)Vmc mutation (0 available); any Tbx3 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:154920 )
• 5 of 13 embryos show complete cleft palate at E18.5

digestive/alimentary system
cleft secondary palate ( J:154920 )
• 5 of 13 embryos show complete cleft palate at E18.5

growth/size/body
cleft secondary palate ( J:154920 )
• 5 of 13 embryos show complete cleft palate at E18.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory