Phenotypes associated with this allele

• Allele Symbol: Tbx2⁺
• Allele Name: wild type
• Allele ID: MGI:2435715
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx2^tm1.1(cre)Vmc/Tbx2^+	involves: 129P2/OlaHsd * NMRI	MGI:4418056
cx2	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418051
cx3	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418053

Genotype
MGI:4418056

ht1

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺
• Genetic Background: involves: 129P2/OlaHsd * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:154920 )

• mice are phenotypically normal on this outbred background

Genotype
MGI:4418051

cx2

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154920 )

• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure

Genotype
MGI:4418053

cx3

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

craniofacial

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

digestive/alimentary system

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

growth/size/body

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5