Phenotypes associated with this allele

• Allele Symbol: Nsd2⁺
• Allele Name: wild type
• Allele ID: MGI:2435612
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nsd2^tm1Ykan/Nsd2^+	involves: 129S2/SvPas * C57BL/6	MGI:3851518
cx2	Nkx2-5^tm1(cre)Rjs/Nkx2-5^+ Nsd2^tm1Ykan/Nsd2^+	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:3851519

Genotype
MGI:3851518

ht1

• Allelic Composition: Nsd2^tm1Ykan/Nsd2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

malocclusion ( J:150360 )

• some mice have malocclusions

postnatal growth retardation ( J:150360 )

• some mice exhibit severe growth retardation

cardiovascular system

abnormal interatrial septum morphology ( J:150360 )

• hypoplasia of the septum secundum was observed more frequently in E18.5 embryos than in controls

craniofacial

malocclusion ( J:150360 )

• some mice have malocclusions

skeleton

malocclusion ( J:150360 )

• some mice have malocclusions

abnormal sternum ossification ( J:150360 )

• mice have a delay in development of sternum ossifications

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Wolf-Hirschhorn syndrome		DOID:0050460	OMIM:194190	J:150360

Genotype
MGI:3851519

cx2

• Allelic Composition: Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺; Nsd2^tm1Ykan/Nsd2⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

cardiovascular system

abnormal interatrial septum morphology ( J:150360 )

• hypoplasia of the septum secundum was observed more frequently in E18.5 embryos than in controls

atrial septal defect ( J:150360 )

• one-third of E18.5 embryos have atrial septum defects

perimembraneous ventricular septal defect ( J:150360 )

• one-third of E18.5 embryos have membranous ventricular septum defects