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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptk2+
wild type
MGI:2435538
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ptk2tm1Imeg/Ptk2+ CBA.Cg-Ptk2tm1Imeg MGI:3689844
ht2
 		Ptk2tm1Itl/Ptk2+ involves: 129S/SvEv * C57BL/6 MGI:4837171
cx3
 		Fyntm1Yik/Fyntm1Yik
Ptk2tm1Lfr/Ptk2+ 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3693516


Genotype
MGI:3689844
ht1
Allelic
Composition		 Ptk2tm1Imeg/Ptk2+
Genetic
Background		 CBA.Cg-Ptk2tm1Imeg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1Imeg mutation (0 available); any Ptk2 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased embryo size ( J:82150 )
• smaller at E8.5

embryo
decreased embryo size ( J:82150 )
• smaller at E8.5

cardiovascular system
abnormal vascular development ( J:82150 )
• appear slightly delayed in vascular development
abnormal dorsal aorta morphology ( J:82150 )
• do not have fully developed dorsal aortas at E8.5




Genotype
MGI:4837171
ht2
Allelic
Composition		 Ptk2tm1Itl/Ptk2+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2tm1Itl mutation (0 available); any Ptk2 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:165360 )
• at P6, but not by 3 to 4 weeks of age




Genotype
MGI:3693516
cx3
Allelic
Composition		 Fyntm1Yik/Fyntm1Yik
Ptk2tm1Lfr/Ptk2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyntm1Yik mutation (1 available); any Fyn mutation (39 available)
Ptk2tm1Lfr mutation (1 available); any Ptk2 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus cortex atrophy ( J:110771 )
• atrophy of the thymic cortex
decreased thymocyte number ( J:110771 )
• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age
abnormal T cell differentiation ( J:110771 )
• impaired development of CD4+CD8+ thymocytes
decreased double-positive T cell number ( J:110771 )
• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy

hematopoietic system
thymus cortex atrophy ( J:110771 )
• atrophy of the thymic cortex
decreased thymocyte number ( J:110771 )
• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age
abnormal T cell differentiation ( J:110771 )
• impaired development of CD4+CD8+ thymocytes
decreased double-positive T cell number ( J:110771 )
• exhibit a reduction in double-positive thymocytes coincident with cortical atrophy

endocrine/exocrine glands
thymus cortex atrophy ( J:110771 )
• atrophy of the thymic cortex
decreased thymocyte number ( J:110771 )
• about 2/3 of mutants start to show a decrease in the number of thymocytes after 3 weeks of age, with numbers dropping as low as 1/100 of normal at 4 to 5 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory