All Phenotypes Fdx1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fdx1⁺
wild type
MGI:2435453

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fdx1^{tm1b(EUCOMM)Wtsi}/Fdx1⁺	C57BL/6N-Fdx1^{tm1b(EUCOMM)Wtsi}/Ieg	MGI:5757109
ht2	Fdx1^tm1Xch/Fdx1⁺	involves: C57BL/6	MGI:7861675

Allelic Composition	Fdx1^{tm1b(EUCOMM)Wtsi}/Fdx1⁺
Genetic Background	C57BL/6N-Fdx1^{tm1b(EUCOMM)Wtsi}/Ieg
Cell Lines	EPD0532_5_D01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fdx1^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Fdx1 mutation (16 available)

Data Sources

IMPC Data for Fdx1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

Allelic Composition	Fdx1^tm1Xch/Fdx1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fdx1^tm1Xch mutation (0 available); any Fdx1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:345826 )

• median lifespan of 73 weeks is shorter than in wild-type mice (117 weeks)

liver/biliary system

hepatic steatosis ( J:345826 )

• mice are highly prone to liver steatosis/steatohepatitis

cellular

abnormal cell morphology ( J:345826 )

• mouse embryo fibroblasts (MEFs) exhibit increased Nile red staining in the cytoplasm suggesting accumulation of lipid droplets

neoplasm

increased adenocarcinoma incidence ( J:345826 )

• while mice are not prone to spontaneous tumors, they exhibit a higher incidence of adenocarcinomas than wild-type mice

increased sarcoma incidence ( J:345826 )

• while mice are not prone to spontaneous tumors, they exhibit a higher incidence of sarcomas than wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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