All Phenotypes Bap1<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bap1^{tm1a(EUCOMM)Hmgu}/Bap1⁺	C57BL/6N-Bap1^{tm1a(EUCOMM)Hmgu}/Wtsi	MGI:5705958
ht2	Bap1^em1Test/Bap1⁺	involves: FVB	MGI:5689167
ht3	Bap1^em2Test/Bap1⁺	involves: FVB	MGI:5817988
ht4	Bap1^em3Test/Bap1⁺	involves: FVB	MGI:5817989
cn5	Bap1^tm1.1Geno/Bap1⁺ Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: C57BL/6 * C57BL/6NTac	MGI:5439659

Allelic Composition	Bap1^{tm1a(EUCOMM)Hmgu}/Bap1⁺
Genetic Background	C57BL/6N-Bap1^{tm1a(EUCOMM)Hmgu}/Wtsi
Cell Lines	HEPD0526_2_G01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bap1^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Bap1 mutation (34 available)

Data Sources

IMPC Data for Bap1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal vibrissa morphology ( J:211773 )

IMPC - WTSI

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased colon tumor incidence ( J:231692 )

• low incidence of colon carcinoma

increased mammary adenocarcinoma incidence ( J:231692 )

• moderate incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

increased incidence of tumors by chemical induction ( J:213725 )

• heterozygotes show a significantly higher incidence and accelerated onset of asbestos-induced malignant mesothelioma (MM), with abdominal swelling noted as early as 20 wks after the first asbestos injection versus 27 wks in wild-type controls

• ultimately, 90% of asbestos-exposed heterozygotes showed abdominal distention, with ~60% of these containing ascites; almost all showed liver anomalies, pancreatic fibrosis, intestinal adhesions, and thickenings of the peritoneum, mesentery, and diaphragm

• heterozygotes exhibited a median survival of 43 wks after initial asbestos exposure versus 55 wks in wild-type controls; 73% of deaths occurred due to peritoneal MM, relative to only 32% in wild-type controls

• although all asbestos-exposed heterozygotes died from MM and other asbestos-related disease by 57 wks, 20% of wild-type controls remained alive and asymptomatic at this time

• in heterozygotes, asbestos-induced MMs were significantly larger and more aggressive than those in wild-type controls, often invading the pancreas, liver, and/or intestinal smooth muscle; occasional metastasis to the lungs was observed

• Ki-67 staining revealed a higher proliferative index in heterozygous MMs relative to wild-type MMs

• in culture, MM cells derived from asbestos-exposed heterozygotes showed loss of expression of the wild-type Bap1 allele, consistent with loss of heterozygosity

• no spontaneous mesotheliomas were detected in untreated heterozygotes up to 87 wks of age

increased skin tumor incidence ( J:231692 )

• low incidence of spindle cell tumor of the skin

increased lung carcinoma incidence ( J:231692 )

• moderate incidence of lung carcinoma

increased squamous cell carcinoma incidence ( J:213725 )

• 1 of 17 heterozygotes developed a spontaneous squamous cell carcinoma (SCC) of mammary origin at 18 months of age

• however, heterozygotes showed no abnormalities of the uvea, skin, mesothelial tissues, or other organs except for the single SCC

increased mesothelioma incidence ( J:231692 )

• low incidence of malignant mesothelioma

digestive/alimentary system

increased colon tumor incidence ( J:231692 )

• low incidence of colon carcinoma

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:213725 )

• although all asbestos-exposed heterozygotes died from MM and other asbestos-related disease by 57 wks, 20% of wild-type controls remained alive and asymptomatic at this time

• Ki-67 staining revealed a higher proliferative index in heterozygous MMs relative to wild-type MMs

• in culture, MM cells derived from asbestos-exposed heterozygotes showed loss of expression of the wild-type Bap1 allele, consistent with loss of heterozygosity

• no spontaneous mesotheliomas were detected in untreated heterozygotes up to 87 wks of age

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:231692 )

• moderate incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

integument

increased mammary adenocarcinoma incidence ( J:231692 )

• moderate incidence of mammary carcinoma

increased skin tumor incidence ( J:231692 )

• low incidence of spindle cell tumor of the skin

cellular

abnormal epigenetic regulation of gene expression ( J:213725 )

• increased susceptibility to asbestos-induced malignant mesothelioma formation may be facilitated, at least in part, by a Cdkn2a-independent mechanism involving epigenetic dysregulation of Rb1

abnormal DNA methylation ( J:213725 )

• malignant mesothelioma (MM) cells derived from heterozygotes exhibit decreased expression of Rb1 due to hypermethylation of the Rb1 promoter

reproductive system

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

hematopoietic system

hematopoietic system phenotype ( J:213725 )

N	• at 3 and 18 months of age, peripheral blood smears and complete blood counts were comparable to those in wild-type controls • at 18 months of age, bone marrow smears showed no evidence of myelodysplastic syndrome (MDS) or other hematologic disease

respiratory system

increased lung carcinoma incidence ( J:231692 )

• moderate incidence of lung carcinoma

Allelic Composition	Bap1^em2Test/Bap1⁺
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bap1^em2Test mutation (0 available); any Bap1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased pancreatic islet cell carcinoma incidence ( J:231692 )

• low incidence of islet cell tumor

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

increased incidence of tumors by chemical induction ( J:231692 )

• 74% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 48 weeks compared to 60 weeks in wild-type mice

increased skin tumor incidence ( J:231692 )

• low incidence of spindle cell tumor of the skin

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma

increased mesothelioma incidence ( J:231692 )

• low incidence of malignant mesothelioma

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased pancreatic islet cell carcinoma incidence ( J:231692 )

• low incidence of islet cell tumor

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:231692 )

• 74% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 48 weeks compared to 60 weeks in wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased skin tumor incidence ( J:231692 )

• low incidence of spindle cell tumor of the skin

reproductive system

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

respiratory system

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma

Allelic Composition	Bap1^em3Test/Bap1⁺
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bap1^em3Test mutation (0 available); any Bap1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

increased incidence of tumors by chemical induction ( J:231692 )

• 71% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 46 weeks compared to 60 weeks in wild-type mice

increased skin tumor incidence ( J:231692 )

• moderate incidence of spindle cell tumor of the skin

increased lymphoma incidence ( J:231692 )

• low incidence of lymphoma

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:231692 )

• 71% of mice chronically injected intraperitoneally with crocidolite asbestos fibers develop peritoneal malignant mesotheliomas compared to 35% of wild-type mice

• asbestos-induced malignant mesotheliomas are larger and more aggressive than in wild-type mice, often with invasion to the pancreas, liver and/or intestinal smooth muscle

• mice injected with asbestos succumb to disease earlier than wild-type mice, with a median survival of 46 weeks compared to 60 weeks in wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:231692 )

• low incidence of mammary carcinoma

increased skin tumor incidence ( J:231692 )

• moderate incidence of spindle cell tumor of the skin

reproductive system

increased ovary tumor incidence ( J:231692 )

• high incidence of ovarian sex cord stromal tumors, mainly granulosa cell tumors

increased granulosa cell tumor incidence ( J:231692 )

respiratory system

increased lung carcinoma incidence ( J:231692 )

• low incidence of lung carcinoma

Allelic Composition	Bap1^tm1.1Geno/Bap1⁺ Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bap1^tm1.1Geno mutation (0 available); any Bap1 mutation (34 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (3 available); any Gt(ROSA)26Sor mutation (1095 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:187380 )

• tamoxifen treatment induces mild but progressive hematological defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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