Bap1^em3Test
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bap1^em3Test
• Name: Brca1 associated protein 1; endonuclease-mediated mutation 3, Joseph R Testa
• MGI ID: MGI:5817987
• Synonyms: Bap1^L
• Gene: Bap1 Location: Chr14:30973407-30981901 bp, + strand Genetic Position: Chr14, 19.09 cM
• Alliance: Bap1^em3Test page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Zinc finger nuclease mediated targeted mutation changed glutamine codon 683 (CAG) in exon 16 to a stop codon (TAG) (p.Q683*). This mutation is the equivalent of the human p.Q684* mutation found in a family with malignant mesothelioma. (J:231692)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bap1^em3Test

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bap1 Mutation: 37 strains or lines available

References

• Original: J:231692 Kadariya Y, et al., Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 May 1;76(9):2836-44
• All: 1 reference(s)