Phenotypes associated with this allele

• Allele Symbol: Tnfaip3⁺
• Allele Name: wild type
• Allele ID: MGI:2435074
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19^+ Tnfaip3^tm2Ama/Tnfaip3^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4831003

Genotype
MGI:4831003

cn1

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Tnfaip3^tm2Ama/Tnfaip3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:163917 )

• B cells are resistant to Fas-mediated programmed cell death compared to controls

increased germinal center B cell number ( J:163917 )

increased plasma cell number ( J:163917 )

• increase in percentage of splenic plasma cells

increased immunoglobulin level ( J:163917 )

• IgM and IgG deposits are seen in the kidneys

increased susceptibility to autoimmune disorder ( J:163917 )

• CpG treatment enhances production of IgG dsDNA antibodies in serum as well as deposition of IgG in renal glomeruli, indicating development of autoimmune disease

increased autoantibody level ( J:163917 )

hematopoietic system

decreased B cell apoptosis ( J:163917 )

• B cells are resistant to Fas-mediated programmed cell death compared to controls

increased germinal center B cell number ( J:163917 )

increased plasma cell number ( J:163917 )

• increase in percentage of splenic plasma cells

increased immunoglobulin level ( J:163917 )

• IgM and IgG deposits are seen in the kidneys

cellular

decreased B cell apoptosis ( J:163917 )

• B cells are resistant to Fas-mediated programmed cell death compared to controls