Analysis Tools|
Allele Symbol Allele Name Allele ID |
Efnb1+ wild type MGI:2434740 |
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| Summary |
14 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fusion occurs in 1 of 7 mice
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• in 2 of 7 mice
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• 10% of mice have preaxial polydactyly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 2 of 2 mice
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N |
• mice exhibit normal skeletal development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 1 of 3 mice
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N |
• mice exhibit normal skeletal development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P1
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• at 16.5, osteroblastic differentiation is delayed
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• at P1
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• at 16.5, osteroblastic differentiation is delayed
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N |
• Background Sensitivity: mice exhibit normal corpus callosum development unlike on a 129S4 background
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• abnormal alignment of the vibrissae buds
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• at P1
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• at 16.5, osteroblastic differentiation is delayed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| craniofrontonasal syndrome | DOID:14737 |
OMIM:304110 |
J:115952 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 1-2% of females survived past weaning
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• ectopic ossifications form in 1 of 5 adults
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• distal carpal bones are fused
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• at E18.5, in 3 of 8 mice and to a lesser extent than in hemizygous Efnb1tm1Rha Tg(Pgk1-cre)1Lni males
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• cartilages corresponding to the distal carpal bones are delayed or sometimes impaired
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• ectopic ossifications form in 1 of 5 adults
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• distal carpal bones are fused
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• 75% of females exhibit polydactyly
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• at E14.5, the body wall is incompletely closed in all embryosat E14.5, the body wall is incompletely closed in all embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less than Mendelian ratios of mice are recovered at 2 weeks after birth
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• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
• Background Sensitivity: on the 129S4/SvJaeSor background defects are restricted to only the last phalange
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less than Mendelian ratios of mice are recovered at 2 weeks after birth
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• 100% of mice have polydactyly restricted to digits I or II of either the hindlimbs or forelimbs
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• the perichondrium around forming digits is poorly organized
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 15% of mice
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• at E14.5, palatal shelves fail to elevate
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• bilaterally defective
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• in 15% of mice
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• at E14.5, palatal shelves fail to elevate
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• in 15% of mice
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• at E14.5, palatal shelves fail to elevate
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at 16.5, osteroblastic differentiation is delayed
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at 16.5, osteroblastic differentiation is delayed
• at E18.5, the frontal bone never overlaps at the coronal suture
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• at E15.5, bone fronts are unable to extend towards each other at the coronal suture
• at 16.5, osteroblastic differentiation is delayed
• at E18.5, the frontal bone never overlaps at the coronal suture
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 40% smaller than in wild type controls
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• at E18.5 eyelids are not fused
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• about 40% smaller than in wild type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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