All Phenotypes Fgf15<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf15⁺
wild type
MGI:2434675

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fgf15^{tm1.1(KOMP)Vlcg}/Fgf15⁺	C57BL/6N-Fgf15^{tm1.1(KOMP)Vlcg}/MbpMmucd	MGI:6325137
ht2	Fgf15^tm1Sms/Fgf15⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3639489
cx3	Fgf15^tm1Sms/Fgf15⁺ Tbx1^tm1Bld/Tbx1⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3639490

Allelic Composition	Fgf15^{tm1.1(KOMP)Vlcg}/Fgf15⁺
Genetic Background	C57BL/6N-Fgf15^{tm1.1(KOMP)Vlcg}/MbpMmucd
Cell Lines	13500A-G3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf15^{tm1.1(KOMP)Vlcg} mutation (1 available); any Fgf15 mutation (17 available)

Data Sources

IMPC Data for Fgf15

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:211773 )

IMPC - UCD

hydrocephaly ( J:211773 )

IMPC - UCD

Allelic Composition	Fgf15^tm1Sms/Fgf15⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf15^tm1Sms mutation (1 available); any Fgf15 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:97317 )

• on a predominantly C57BL/6 genetic background, heterozygotes are obtained at a slightly reduced Mendelian frequency between P0 and P7 (44.44% vs expected 50%)

cardiovascular system

overriding aortic valve ( J:97317 )

• at E18.5, 9.1% of heterozygotes display an overriding aorta; however, no aortic arch patterning defects are observed

ventricular septal defect ( J:97317 )

• at E18.5, 18.2% of heterozygotes exhibit muscular and membranous ventricular septal defects

perimembraneous ventricular septal defect ( J:97317 )

muscular ventricular septal defect ( J:97317 )

Allelic Composition	Fgf15^tm1Sms/Fgf15⁺ Tbx1^tm1Bld/Tbx1⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf15^tm1Sms mutation (1 available); any Fgf15 mutation (17 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aortic arch development ( J:97317 )

• at E18.5, double heterozygotes show no significant increase in the penetrance or severity of aortic arch patterning defects relative to Tbx1^tm1Bld heterozygotes

• observed defects include interrupted aortic arch type-B (20%), aberrant origin of the right subclavian artery (30%), and VSDs (membranous 20%; muscular: 10%)

aberrant origin of the right subclavian artery ( J:97317 )

interrupted aortic arch ( J:97317 )

perimembraneous ventricular septal defect ( J:97317 )

muscular ventricular septal defect ( J:97317 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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