Phenotypes associated with this allele

• Allele Symbol: Aurka⁺
• Allele Name: wild type
• Allele ID: MGI:2434571
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Aurka^tm1b(EUCOMM)Hmgu/Aurka^+	B6N(Cg)-Aurka^tm1b(EUCOMM)Hmgu/J	MGI:5797391
ht2	Aurka^Gt(XQ0149)Wtsi/Aurka^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4456487

Genotype
MGI:5797391

ht1

• Allelic Composition: Aurka^{tm1b(EUCOMM)Hmgu}/Aurka⁺
• Genetic Background: B6N(Cg)-Aurka^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0510_4_F05

Data Sources

IMPC Data for Aurka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - JAX

hematopoietic system

decreased leukocyte cell number ( J:211773 )

IMPC - JAX

immune system

decreased leukocyte cell number ( J:211773 )

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - JAX

vision/eye

sclerocornea ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:4456487

ht2

• Allelic Composition: Aurka^{Gt(XQ0149)Wtsi}/Aurka⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:143099 )

• frequency of tumors is 25.5% compared to 8.8% in controls

• tumors are found in various organs including the thymus, liver, lung and lymph nodes

increased hepatoma incidence ( J:143099 )

• seen in one mouse

increased lymphoma incidence ( J:143099 )

• most tumors are lymphomas that invade the lung

increased lung carcinoma incidence ( J:143099 )

• seen in 5 cases

increased squamous cell carcinoma incidence ( J:143099 )

• seen in one mouse

cellular

aneuploidy ( J:143099 )

• increase in the percentage of MEFs displaying aneuploidy compared to controls

chromosomal instability ( J:143099 )

• MEFS have about 70% more cells containing greater than 4N content

liver/biliary system

increased hepatoma incidence ( J:143099 )

• seen in one mouse

respiratory system

increased lung carcinoma incidence ( J:143099 )

• seen in 5 cases