Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mcm4+ wild type MGI:2434466 |
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| Summary |
12 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in moribund mice
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• in moribund mice
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• hematologic malignancy including mediastinal masses, splenomegaly and/or lymphadenopathy in 180 of 191 moribund mice
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• early onset T cell acute lymphoblastic leukemia (T-ALL)
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• in mouse embryonic fibroblasts in the presence or absence of aphidicolin
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• in mouse embryonic fibroblasts in the presence or absence of aphidicolin
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• in moribund mice
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• 18-fold increase in micronucleated reticulocytes
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• in moribund mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show 2- to 5-fold elevated micronucleus frequencies compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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