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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad50+
wild type
MGI:2434296
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		\Rad50tm5Jpt/\Rad50+ involves: 129/Sv * C57BL/6 MGI:5614072
ht2
 		\Rad50tm4.1Jpt/\Rad50+ involves: 129/Sv * C57BL/6 MGI:5614073
ht3
 		\Rad50tm4Jpt/\Rad50+ involves: 129/Sv * C57BL/6 MGI:5614081
ht4
 		\Atmtm1Awb/\Atm+ involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614077
cx5
 		\Atmtm1Awb/\Atmtm1Awb
\Rad50tm4.1Jpt/\Rad50+ 		involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614078
cx6
 		\Rad50tm4.1Jpt/\Rad50+
\Spo11tm1Mjn/\Spo11tm1Mjn 		involves: 129/Sv * C57BL/6 MGI:5614080


Genotype
MGI:5614072
ht1
Allelic
Composition		 \Rad50tm5Jpt/\Rad50+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm5Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:209141 )
• no live mice are found at birth




Genotype
MGI:5614073
ht2
Allelic
Composition		 \Rad50tm4.1Jpt/\Rad50+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased liver tumor incidence ( J:209141 )
• multiple liver neoplasms are seen in 37% of mice
• most affected mice present hyperplastic nodules and/or adenomas
increased hepatoblastoma incidence ( J:209141 )
• malignant hepatoblastomas are seen in 10% of mice

reproductive system
abnormal seminiferous tubule morphology ( J:209141 )
• severely reduced cellularity
small testis ( J:209141 )
• 2-fold smaller than in mutant mice heterozygous for Atmtm1Awb
abnormal sperm number ( J:209141 )
• decrease in the number of meiotic cells
abnormal spermatogenesis ( J:209141 )
• increase in the number of primitive precursors, decrease in the number of meiotic cells and no increase in cell death is consistent with a block in spematogonial differentiation
female infertility ( J:209141 )
• 27% of females are infertile
reduced female fertility ( J:209141 )
• 73% of females produce fewer and smaller litters
decreased litter size ( J:209141 )
• 73% of females produce fewer and smaller litters
male infertility ( J:209141 )
• all males are infertile

hematopoietic system
impaired hematopoiesis ( J:209141 )
• a 50% reduction in the colony forming ability of multipotent precursors
abnormal hematopoietic stem cell morphology ( J:209141 )
• altered LSK population with an expansion of the multipotent precursors
• no increase in proximal descendants of the multipotent precursors is detected

nervous system
hydrocephaly ( J:209141 )
• in 27% of mice

neoplasm
increased liver tumor incidence ( J:209141 )
• multiple liver neoplasms are seen in 37% of mice
• most affected mice present hyperplastic nodules and/or adenomas
increased hepatoblastoma incidence ( J:209141 )
• malignant hepatoblastomas are seen in 10% of mice

pigmentation
increased skin pigmentation ( J:209141 )
• intense skin hyperpigmentation

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:209141 )
• severely reduced cellularity
small testis ( J:209141 )
• 2-fold smaller than in mutant mice heterozygous for Atmtm1Awb

limbs/digits/tail

integument
increased skin pigmentation ( J:209141 )
• intense skin hyperpigmentation




Genotype
MGI:5614081
ht3
Allelic
Composition		 \Rad50tm4Jpt/\Rad50+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm4Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
hydrocephaly ( J:209141 )
• in 4% of mice

neoplasm
increased liver tumor incidence ( J:209141 )
• multiple liver neoplasms are seen in 26% of mice
• most affected mice present hyperplastic nodules and/or adenomas

liver/biliary system
increased liver tumor incidence ( J:209141 )
• multiple liver neoplasms are seen in 26% of mice
• most affected mice present hyperplastic nodules and/or adenomas




Genotype
MGI:5614077
ht4
Allelic
Composition		 \Atmtm1Awb/\Atm+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (167 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:209141 )
• cellularity is increased compared to mutant mice wild-type for Atm
abnormal testis size ( J:209141 )
• 2-fold larger than in mutant mice wild-type for Atm

hematopoietic system
hematopoietic system phenotype ( J:209141 )
N
• unlike mutant mice wild-type for Atm, the LSK population is similar to wild-type controls

nervous system
nervous system phenotype ( J:209141 )
N
• unlike mutant mice wild-type for Atm, no mice with hydrocephaly are seen

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:209141 )
• cellularity is increased compared to mutant mice wild-type for Atm
abnormal testis size ( J:209141 )
• 2-fold larger than in mutant mice wild-type for Atm




Genotype
MGI:5614078
cx5
Allelic
Composition		 \Atmtm1Awb/\Atmtm1Awb
\Rad50tm4.1Jpt/\Rad50+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (167 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor latency ( J:209141 )
• marked increase in the latency of thymic lymphomas compared to mutant mice wild-type for Rad50




Genotype
MGI:5614080
cx6
Allelic
Composition		 \Rad50tm4.1Jpt/\Rad50+
\Spo11tm1Mjn/\Spo11tm1Mjn
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:209141 )
• severely reduced cellularity

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:209141 )
• severely reduced cellularity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory