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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17a+
wild type
MGI:2433865
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17a+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5462357
cx2
 		Il1rntm1Yiw/Il1rntm1Yiw
Il17atm1Yiw/Il17a+ 		involves: 129P2/OlaHsd * BALB/cA * C57BL/6J MGI:3590199


Genotype
MGI:5462357
cx1
Allelic
Composition		 Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Il17atm1Yiw mutation (0 available); any Il17a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:191090 )
• about 35.7% of mutants are alive after 12 months of age
premature death ( J:191090 )
• about 35.7% of mutants are alive after 12 months of age

immune system
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system
increased spleen germinal center number ( J:191090 )
• develop spontaneous germinal centers

renal/urinary system
kidney inflammation ( J:191090 )
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions




Genotype
MGI:3590199
cx2
Allelic
Composition		 Il1rntm1Yiw/Il1rntm1Yiw
Il17atm1Yiw/Il17a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cA * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (24 available)
Il1rntm1Yiw mutation (0 available); any Il1rn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:83408 )
• reduced incidence of arthritis
• severity of arthritis not reduced

skeleton
decreased susceptibility to induced arthritis ( J:83408 )
• reduced incidence of arthritis
• severity of arthritis not reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory