Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gata6+ wild type MGI:2433814 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• fewer than expected proportion of primitive endoderm cells in early embryos
• however, primitive endoderm populations have recovered by E4.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• heterozygote x wild-type matings produce fewer heterozygotes than the expected Mendelian ratios
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutants are viable through E15.5, with a small number recovered at weaning
|
|
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only 7% (instead of expected 25%) of double heterozygotes are recovered at 2 weeks of age
• however, normal numbers are obtained prior to birth (E18.5)
|
|
• at E18.5, airway development and differentiation of the distal epithelium are severely impaired, as shown by increased mesenchymal thickness, reduced sacculation, decreased surfactant production and increased glycogen content
• however, lung-to-body weight ratios and tidal volumes are not significantly altered
|
|
• at E18.5, lung sacculation is significantly reduced in the distal airways
|
|
• at E18.5, a 2-fold increase in mesenchymal thickness is observed
|
|
• at E18.5, lung epithelial differentiation is severely impaired, as shown by a more focal surfactant protein C (SP-C) protein expression pattern, reduced CC10 (Clara-cell-marker) protein expression, and a more tight, focal expression of aquaporin-5 and SP-C that is less evenly distributed throughout the distal airspaces
|
|
• distal airway cells are lined with large cuboidal cells that contain large glycogen-filled vacuoles but lack lamellar bodies
|
|
• lamellar bodies are either absent or only rarely observed
|
|
• at 3-5 months of age, a ~60% reduction in phospholipid content is noted in bronchioalveolar lavage fluid
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• lethality by E13.5
|
|
• cranial and intersomitic vasculature is enlarged and disorganized at E10.5
• exhibit thin and dilated vessels
|
|
• hypoplastic transcending aortic arch
|
|
• hypoplastic aorta at E12.5
|
|
• dilated aorta at E12.5
|
|
• show a reduction in the arterial smooth muscle
|
|
• at E12.5, mutants show less smooth muscle in the medial layer of the aorta
|
|
• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers
|
|
• myocardial thinning becomes apparent at E12.5
|
|
• exhibit patterning defects of the outflow tract at E12
|
|
• seen at E12, resulting from incomplete septation of the conotruncus into the aorta and pulmonary artery
|
|
• exhibit a modest delay in the formation of the ventricular septum beginning at E11.5
|
|
• show ventricular septal defects that persist until death
|
|
• display widespread hemorrhages by E11.5
|
|
• display reduced cardiomyocyte proliferation at E10.5
|
|
• heartbeat at E11.75 is sluggish and irregular
|
|
• reduction in the number of mature erythrocytes in peripheral blood
|
|
• show a reduction in the arterial smooth muscle
|
|
• at E12.5, mutants show less smooth muscle in the medial layer of the aorta
|
|
• hearts at E13.5 contain only two myocardial cell layers within the compact zone instead of the normal five layers
|
|
• myocardial thinning becomes apparent at E12.5
|
|
• display reduced cardiomyocyte proliferation at E10.5
|
|
• display reduced cardiomyocyte proliferation at E10.5
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/31/2026 MGI 6.24 |
|
|
|
||
