All Phenotypes Atm<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atm⁺
wild type
MGI:2433772

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atm^tm1Pmc/Atm⁺	B6.Cg-Atm^tm1Pmc	MGI:5644543
ht2	Atm^tm1Awb/Atm⁺	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:5614077
ht3	Atm^tm1Mfl/Atm⁺	involves: 129T2/SvEms * C57BL/6J	MGI:3702914
cx4	Atm^tm1Pmc/Atm⁺ Lig4^tm1Icrf/Lig4^tm1Icrf	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3655374
cx5	Atm^tm1Led/Atm⁺ Kat8^tm2Thl/Kat8⁺	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3769385
cx6	Atm^tm1Awb/Atm⁺ Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:3615669

Allelic Composition	Atm^tm1Pmc/Atm⁺
Genetic Background	B6.Cg-Atm^tm1Pmc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Pmc mutation (0 available); any Atm mutation (167 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:222034 )

• males fed a high-fat diet exhibit glucose intolerance and insulin resistance

• however, mice fed a normal diet do not exhibit glucose intolerance

insulin resistance ( J:222034 )

• males fed a high-fat diet exhibit glucose intolerance and insulin resistance

• however, mice fed a normal diet do not exhibit insulin resistance

Allelic Composition	Atm^tm1Awb/Atm⁺
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Awb mutation (7 available); any Atm mutation (167 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:209141 )

• cellularity is increased compared to mutant mice wild-type for Atm

abnormal testis size ( J:209141 )

• 2-fold larger than in mutant mice wild-type for Atm

hematopoietic system

hematopoietic system phenotype ( J:209141 )

N	• unlike mutant mice wild-type for Atm, the LSK population is similar to wild-type controls

nervous system

nervous system phenotype ( J:209141 )

N	• unlike mutant mice wild-type for Atm, no mice with hydrocephaly are seen

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:209141 )

• cellularity is increased compared to mutant mice wild-type for Atm

abnormal testis size ( J:209141 )

• 2-fold larger than in mutant mice wild-type for Atm

Allelic Composition	Atm^tm1Mfl/Atm⁺
Genetic Background	involves: 129T2/SvEms * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Mfl mutation (3 available); any Atm mutation (167 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:78527 )

• elevated tumor incidence

• average age at onset 18.6 months

• varying tumor types including dermatoid cysts

increased ovary tumor incidence ( J:78527 )

• 8% of total

increased adenoma incidence ( J:78527 )

• 13% of total

increased leukemia incidence ( J:78527 )

• 5% of total

increased lymphoma incidence ( J:78527 )

• 24% of total

increased sarcoma incidence ( J:78527 )

• 32% of total

• half of sarcomas are in Mammary glands

reproductive system

increased ovary tumor incidence ( J:78527 )

• 8% of total

endocrine/exocrine glands

increased ovary tumor incidence ( J:78527 )

• 8% of total

Allelic Composition	Atm^tm1Pmc/Atm⁺ Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Pmc mutation (0 available); any Atm mutation (167 available)
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

cellular

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

Allelic Composition	Atm^tm1Led/Atm⁺ Kat8^tm2Thl/Kat8⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Led mutation (0 available); any Atm mutation (167 available)
Kat8^tm2Thl mutation (0 available); any Kat8 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:128936 )

• only 76% of mice survive the first year

Allelic Composition	Atm^tm1Awb/Atm⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Awb mutation (7 available); any Atm mutation (167 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50^tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm

increased lymphoma incidence ( J:103922 )

• 16 of 67 develop lymphoma

hematopoietic system

anemia ( J:103922 )

• most succumb to anemia

decreased macrophage cell number ( J:103922 )

• macrophage counts are decreased to a similar level as in homozygous Atm^tm1Awb mice

immune system

decreased macrophage cell number ( J:103922 )

• macrophage counts are decreased to a similar level as in homozygous Atm^tm1Awb mice

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