All Phenotypes Zic2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zic2⁺
wild type
MGI:2433715

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zic2^tm1Jaru/Zic2⁺	B6.129S4-Zic2^tm1Jaru	MGI:2653210
ht2	Zic2^Ku/Zic2⁺	C3.CAnNCrl-Zic2^Ku	MGI:3639580
ht3	Zic2^tm1Jaru/Zic2⁺	involves: 129S4/SvJae * C57BL/6J	MGI:5085985
ht4	Zic2^Ku/Zic2⁺	involves: BALB/c * C3H/HeN	MGI:2175095
ht5	Zic2^em4Bend/Zic2⁺	involves: C3H/HeH	MGI:5566860
ht6	Zic2^em2Bend/Zic2⁺	involves: C3H/HeH	MGI:5566858
ht7	Zic2^em3Bend/Zic2⁺	involves: C3H/HeH	MGI:5566859
ht8	Zic2^em5Bend/Zic2⁺	involves: C3H/HeH	MGI:5566861
ht9	Zic2^em1Bend/Zic2⁺	involves: C57BL/6J	MGI:5566857
cx10	Nodal^tm2Rob/Nodal^tm2Rob Zic2^Ku/Zic2⁺	129S.Cg-Nodal^tm2Rob Zic2^Ku	MGI:5827604
cx11	Shh⁺/Shh^tm1Chg Zic2^Ku/Zic2⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH	MGI:5827502

Allelic Composition	Zic2^tm1Jaru/Zic2⁺
Genetic Background	B6.129S4-Zic2^tm1Jaru

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^tm1Jaru mutation (1 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:72342 )

N	• mutants exhibit normal spontaneous locomotor activity, motor coordination ability, neuromuscular strength, motivation and emotional behavior

increased startle reflex ( J:72342 )

• acoustic startle response is larger, with an amplitude twice that of wild-type

nervous system

decreased prepulse inhibition ( J:72342 )

• the prepulse inhibition level is attenuated both with the 70-dB and 80-dB prepulses

Allelic Composition	Zic2^Ku/Zic2⁺
Genetic Background	C3.CAnNCrl-Zic2^Ku

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^Ku mutation (4 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:86841 )

• partial penetrance

kinked tail ( J:86841 )

• partial penetrance of distal tail kink

nervous system

spina bifida ( J:86841 )

• seen in a small proportion of heterozygotes

pigmentation

belly spot ( J:86841 )

• partial penetrance of ventral spotting

embryo

spina bifida ( J:86841 )

• seen in a small proportion of heterozygotes

integument

belly spot ( J:86841 )

• partial penetrance of ventral spotting

Allelic Composition	Zic2^tm1Jaru/Zic2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^tm1Jaru mutation (1 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:174352 )

N	• mice exhibit normal responses in the light-dark box test, marble burying test, elevated plus maze test, forced swimming test, grip strength test, wire hanging test, footprint test, and rotarod test

impaired contextual conditioning behavior ( J:174352 )

impaired cued conditioning behavior ( J:174352 )

• slight

abnormal spatial learning ( J:174352 )

• in a Morris water maze, mice exhibit increased latency to training and reverse compared with wild-type mice

abnormal spatial working memory ( J:174352 )

• in a Y maze, mice exhibit an increase in number of entries and a decrease in alternation compared with wild-type mice

decreased aggression towards mice ( J:174352 )

• mice are often the losers in a social dominance test unlike wild-type mice

decreased locomotor activity ( J:174352 )

• in a home cage

hyperactivity ( J:174352 )

• in an open field test

nervous system

decreased brain size ( J:174352 )

enlarged lateral ventricles ( J:174352 )

• most notable in the anterior horn region

• with reduction in the mass of the septum

abnormal amygdala morphology ( J:174352 )

• in 6 of 8 mice, the medial protrusion of the amygdala in the coronal sections is blunted compared to in wild-type mice

abnormal cerebral hemisphere morphology ( J:174352 )

• the position and shape of the medial structure rostral to the hippocampus were narrower than in wild-type mice

decreased corpus callosum size ( J:174352 )

• slight thinner than in wild-type mice

thin cerebral cortex ( J:174352 )

• slight

decreased neuron number ( J:174352 )

• the number of cholinergic neurons are decreased in the basal forebrain compared to in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:174352

Allelic Composition	Zic2^Ku/Zic2⁺
Genetic Background	involves: BALB/c * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^Ku mutation (4 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:63816 )

limbs/digits/tail

curly tail ( J:63816 )

integument

belly spot ( J:63816 )

Allelic Composition	Zic2^em4Bend/Zic2⁺
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^em4Bend mutation (0 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Curly tail in a Zic2^em4Bend/Zic2⁺ founder

limbs/digits/tail

curly tail ( J:199882 )

• partial penetrance

Allelic Composition	Zic2^em2Bend/Zic2⁺
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^em2Bend mutation (0 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:199882 )

• partial penetrance

Allelic Composition	Zic2^em3Bend/Zic2⁺
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^em3Bend mutation (0 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:199882 )

• partial penetrance

Allelic Composition	Zic2^em5Bend/Zic2⁺
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^em5Bend mutation (0 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:199882 )

• partial penetrance

Allelic Composition	Zic2^em1Bend/Zic2⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic2^em1Bend mutation (0 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Curly tail in a Zic2^em1Bend/Zic2⁺ founder

limbs/digits/tail

curly tail ( J:199882 )

• partial penetrance

Allelic Composition	Nodal^tm2Rob/Nodal^tm2Rob Zic2^Ku/Zic2⁺
Genetic Background	129S.Cg-Nodal^tm2Rob Zic2^Ku

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodal^tm2Rob mutation (0 available); any Nodal mutation (41 available)
Zic2^Ku mutation (4 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

rostral body truncation ( J:238567 )

• 72% of embryos present with moderate to severe anterior truncation

Allelic Composition	Shh⁺/Shh^tm1Chg Zic2^Ku/Zic2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (1 available); any Shh mutation (45 available)
Zic2^Ku mutation (4 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:138862 )

• trans-heterozygotes do not exhibit any defects characteristic of either single homozygote

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