Phenotypes associated with this allele

• Allele Symbol: Slc18a2⁺
• Allele Name: wild type
• Allele ID: MGI:2433713
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slc18a2^tm1Mca/Slc18a2^+	B6.129X1-Slc18a2^tm1Mca	MGI:3852389
ht2	Slc18a2^tm1Uhl/Slc18a2^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3622426
ht3	Slc18a2^tm1Mca/Slc18a2^+	involves: 129X1/SvJ	MGI:3852385
ht4	Slc18a2^tm1Edw/Slc18a2^+	involves: 129X1/SvJ * C57BL/6	MGI:3582059
ht5	Slc18a2^tm1Mca/Slc18a2^+	involves: 129X1/SvJ * C57BL/6J	MGI:3852390

Genotype
MGI:3852389

ht1

• Allelic Composition: Slc18a2^tm1Mca/Slc18a2⁺
• Genetic Background: B6.129X1-Slc18a2^tm1Mca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enhanced long-term potentiation ( J:89778 )

• significant enhancement of long term potentiation in a minimal tetanus assay

behavior/neurological

behavior/neurological phenotype ( J:125273 )

N • mice do not display abnormal anxiety like behaviors

abnormal associative learning ( J:125273 )

• impairment in learned helplessness behavior

abnormal liquid preference ( J:125273 )

• reduced sucrose-water to water preference ratios at 1% and 1.5% sucrose compared to wild-type controls

decreased coping response ( J:125273 )

• significant increase in immobility time in a forced swim test or a tail suspension test

• treatment with antidepressants decreases immobility times

decreased vertical activity ( J:125273 )

• in an open field test

decreased locomotor activity ( J:125273 )

• in an open field test

homeostasis/metabolism

abnormal corticosterone level ( J:125273 )

• increase in corticosterone levels under stressful conditions but not under basal conditions

Genotype
MGI:3622426

ht2

• Allelic Composition: Slc18a2^tm1Uhl/Slc18a2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

behavior/neurological

enhanced behavioral response to addictive substance ( J:42811 )

• amphetamine-induced increases in locomotion are enhanced relative to controls

impaired conditioned place preference behavior ( J:42811 )

• amphetamine produces diminished behavioral reward relative to controls, as measured by conditioned place preference

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:42811 )

• N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration produces more than twice the dopamine cell losses

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:42811 )

• N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration produces more than twice the dopamine cell losses

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:42811 )

• N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration produces more than twice the dopamine cell losses

mortality/aging

premature death ( J:42811 , J:57671 )

• approximately 10% of heterozygous animals die in midlife without apparent cause (J:42811)

• ten to fifteen percent of heterozygous mice die suddenly before 6 months of age with no apparent cause (J:57671)

cardiovascular system

prolonged QT interval ( J:57671 )

• freely moving heterozygous mice display significantly prolonged QT intervals compared with controls, suggesting vulnerability to lethal arrhythmias

• QTc values were also prolonged in heterozygotes compared to controls

• heterozygous mutant mice displayed no significant heart rate differences from wild type mice when resting, and baseline locomotor activities did not differ between mutant and control mice

Genotype
MGI:3852385

ht3

• Allelic Composition: Slc18a2^tm1Mca/Slc18a2⁺
• Genetic Background: involves: 129X1/SvJ

nervous system

abnormal neurotransmitter secretion ( J:45184 )

• marked reduction in amphetamine evoked striatal dopamine release in freely moving mice

abnormal neurotransmitter uptake ( J:45184 )

• about a 50% reduction in the initial rate of dopamine uptake in vesicular preparations from adult striata

behavior/neurological

impaired behavioral response to cocaine ( J:45184 )

• following chronic exposure to cocaine no increase in behavioral response is seen following a challenge dose unlike in wild-type mice

enhanced behavioral response to addictive substance ( J:45184 )

• marked increase in behavioral response to apomorphine, cocaine, and amphetamine compared to similarly treated wild-type mice

homeostasis/metabolism

decreased dopamine level ( J:45184 )

• dopamine content in the striata is about 25% lower than in wild-type mice, but the level of the dopamine metabolite, DOPAC, is significantly increased

• extracellular striatal dopamine levels are reduced by about 40% compared to wild-type mice

decreased physiological sensitivity to xenobiotic ( J:45184 )

• marked reduction in amphetamine evoked striatal dopamine release in freely moving mice

Genotype
MGI:3582059

ht4

• Allelic Composition: Slc18a2^tm1Edw/Slc18a2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

homeostasis/metabolism

decreased dopamine level ( J:45183 )

• contain 58% as much dopamine as wildtype

• midbrain cultures contain only about 75% as much dopamine as control cultures and release 47% as much dopamine in response to depolarization for 2 min with elevated potassium

abnormal noradrenaline level ( J:45183 )

• contain 77% as much norepinephrine as wildtype

abnormal serotonin level ( J:45183 )

• contain 66% as much serotonin as wildtype

Genotype
MGI:3852390

ht5

• Allelic Composition: Slc18a2^tm1Mca/Slc18a2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:124481 )

N • no difference in activity is seen in mice that consumed saline or alcohol compared to matched wild-type controls

decreased alcohol consumption ( J:124481 )

• male mice show a marked decrease in alcohol consumption compared to wild-type males

impaired conditioned place preference behavior ( J:124481 )

• mice do not display a preference for the environment paired with ethanol in a place preference assay

abnormal liquid preference ( J:124481 )

• slight but significant decrease in preference for saccharin water in males compared to wild-type males