All Phenotypes Glg1<+> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show significantly decreased numbers of firmly attached leukocytes on endothelial cells in cremaster venules relative to wild-type controls

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

hematopoietic system

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cellular

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:226586 )

• heterozygotes are viable and develop normally with no apparent phenotypic abnormalities in the unchallenged state

• at 18 weeks of age, heterozygotes fed a high-fat, high-sucrose diet for 10 weeks display an impaired endothelial-dependent relaxation response to acetylcholine, that is similar in extent to that seen in wild-type controls

Allelic Composition	Glg1^{tm1a(KOMP)Wtsi}/Glg1⁺
Genetic Background	C57BL/6N-Glg1^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0269_2_C07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1^{tm1a(KOMP)Wtsi} mutation (2 available); any Glg1 mutation (68 available)

Data Sources

IMPC Data for Glg1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glycerol level ( J:211773 )

IMPC - WTSI

increased circulating triglyceride level ( J:211773 )

IMPC - WTSI

skeleton

abnormal vertebral arch morphology ( J:211773 )

IMPC - WTSI

Allelic Composition	Fgf18^tm1Sjt/Fgf18⁺ Glg1^{Gt(KST005)Byg}/Glg1⁺
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18^tm1Sjt mutation (0 available); any Fgf18 mutation (12 available)
Glg1^{Gt(KST005)Byg} mutation (1 available); any Glg1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

Allelic Composition	Fgf18^tm1Sjt/Fgf18^tm1Sjt Glg1^{Gt(KST005)Byg}/Glg1⁺
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

skeleton

abnormal rib morphology ( J:157157 )

• mice die at birth

abnormal spine curvature ( J:157157 )

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Glg1^{Gt(RST092)Byg}/Glg1⁺
Genetic Background	B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (35 available); any Apoe mutation (164 available)
Glg1^{Gt(RST092)Byg} mutation (0 available); any Glg1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:226586 )

N	• mice exhibit no significant differences in right and left ventricular chamber thickness or in myocardial collagen deposition relative to Apoe^tm1Unc homozygotes

atherosclerotic lesions ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit atherosclerotic lesions with increased collagen deposition and fewer macrophages per mm2 of lesion relative to lesions from Apoe^tm1Unc homozygotes, as shown by collagen-specific (Sirius Red) and macrophage-specific (CD68) staining of aortic valves

• altered lesion composition suggests increased plaque stability; however, no differences in lesion area and thickness or in accumulation of smooth muscle cells are observed relative to Apoe^tm1Unc homozygotes

immune system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased collagen level ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit significantly increased collagen deposition in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

cellular

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24