Phenotypes associated with this allele

• Allele Symbol: Rora⁺
• Allele Name: wild type
• Allele ID: MGI:2433376
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rora^tm1b(EUCOMM)Wtsi/Rora^+	C57BL/6N-Rora^tm1b(EUCOMM)Wtsi/Ieg	MGI:5759440
ht2	Rora^sg/Rora^+	involves: C57BL	MGI:4835189
ht3	Rora^sg/Rora^+	involves: C57BL/6J	MGI:4820957

Genotype
MGI:5759440

ht1

• Allelic Composition: Rora^{tm1b(EUCOMM)Wtsi}/Rora⁺
• Genetic Background: C57BL/6N-Rora^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0157_5_B01

Data Sources

IMPC Data for Rora

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased startle reflex ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - HMGU

Genotype
MGI:4835189

ht2

• Allelic Composition: Rora^sg/Rora⁺
• Genetic Background: involves: C57BL

nervous system

abnormal inferior olivary complex morphology ( J:1431 )

• neuron counts are 60% of controls at 1 year of age

abnormal cerebellum morphology ( J:1431 )

abnormal cerebellar layer morphology ( J:1431 )

decreased Purkinje cell number ( J:1431 )

• significant loss of Purkinje cells at 1 year of age

abnormal cerebellar granule layer morphology ( J:1431 )

• granule cell layer decreases with age

• cell density is reduced

decreased cerebellar granule cell number ( J:1431 )

• cell numbers are about 35% of controls

small cerebellum ( J:1431 )

• decreased cross-sectional area of the cerebellum at 1 year of age

Genotype
MGI:4820957

ht3

• Allelic Composition: Rora^sg/Rora⁺
• Genetic Background: involves: C57BL/6J

behavior/neurological

abnormal spatial learning ( J:30686 )

• mice exhibit impaired spatial learning in a Z-maze filled with water compared with wild-type mice