Phenotypes associated with this allele

• Allele Symbol: Bmp7⁺
• Allele Name: wild type
• Allele ID: MGI:2433196
• Summary: 12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bmp7^tm1a(EUCOMM)Hmgu/Bmp7^+	C57BL/6N-Bmp7^tm1a(EUCOMM)Hmgu/H	MGI:5782036
cn2	Bmp2^tm1Jfm/Bmp2^+ Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312871
cn3	Bmp2^tm1Jfm/Bmp2^tm1Jfm Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312875
cn4	Bmp2^tm1Jfm/Bmp2^tm1Jfm Bmp4^tm1Jfm/Bmp4^+ Bmp7^tm1Jfm/Bmp7^+ H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312870
cn5	Bmp7^tm6(cre)Rob/Bmp7^+ Smad4^tm1Rob/Smad4^tm1.1Rob	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3628946
cn6	Bmp2^tm1Cjt/Bmp2^+ Bmp7^tm1Rob/Bmp7^+ Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700045
cn7	Bmp2^tm1Cjt/Bmp2^tm1Cjt Bmp7^tm1Rob/Bmp7^+ Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700043
cx8	Bmp7^tm1Rob/Bmp7^+ Fbn2^tm1Rmz/Fbn2^+	either: (involves: 129/Sv * 129S/SvEv) or (involves: 129/Sv * 129S/SvEv * C57BL/6J)	MGI:3641531
cx9	Bmp4^tm1Blh/Bmp4^+ Bmp7^tm1Kry/Bmp7^+	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:3047090
cx10	Bmp7^tm1Rob/Bmp7^+ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss	MGI:2451055
cx11	Bmp7^tm1Rob/Bmp7^+ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6	MGI:2451053
cx12	Bmp2^tm1Brd/Bmp2^+ Bmp7^tm1Kry/Bmp7^+	Not Specified	MGI:3047104

Genotype
MGI:5782036

ht1

• Allelic Composition: Bmp7^{tm1a(EUCOMM)Hmgu}/Bmp7⁺
• Genetic Background: C57BL/6N-Bmp7^{tm1a(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0510_3_C07

Data Sources

IMPC Data for Bmp7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased erythrocyte cell number ( J:165965 )

IMPC - HAR

increased mean corpuscular volume ( J:165965 )

IMPC - HAR

increased monocyte cell number ( J:165965 )

♂

IMPC - HAR

immune system

increased monocyte cell number ( J:165965 )

♂

IMPC - HAR

Genotype
MGI:5312871

cn2

• Allelic Composition: Bmp2^tm1Jfm/Bmp2⁺; Bmp4^tm1Jfm/Bmp4^tm1Jfm; Bmp7^tm1Jfm/Bmp7⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

craniofacial

small alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

hearing/vestibular/ear

decreased tympanic ring size ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

skeleton

small alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

growth/size/body

small nasal bone ( J:181229 )

cleft palate ( J:181229 )

respiratory system

small nasal bone ( J:181229 )

Genotype
MGI:5312875

cn3

• Allelic Composition: Bmp2^tm1Jfm/Bmp2^tm1Jfm; Bmp4^tm1Jfm/Bmp4^tm1Jfm; Bmp7^tm1Jfm/Bmp7⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

craniofacial

abnormal interparietal bone morphology ( J:181229 )

• pieces of the interparietal bone are absent

absent alisphenoid bone ( J:181229 )

absent temporal bone squamous part ( J:181229 )

abnormal mandibular angle morphology ( J:181229 )

• decreased size

abnormal mandibular condyloid process morphology ( J:181229 )

• pieces of the condyloid process are absent

absent mandibular coronoid process ( J:181229 )

absent maxilla ( J:181229 )

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

absent zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

hearing/vestibular/ear

absent tympanic ring ( J:181229 )

skeleton

abnormal interparietal bone morphology ( J:181229 )

• pieces of the interparietal bone are absent

absent alisphenoid bone ( J:181229 )

absent temporal bone squamous part ( J:181229 )

abnormal mandibular angle morphology ( J:181229 )

• decreased size

abnormal mandibular condyloid process morphology ( J:181229 )

• pieces of the condyloid process are absent

absent mandibular coronoid process ( J:181229 )

absent maxilla ( J:181229 )

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

absent zygomatic bone ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

growth/size/body

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

cleft palate ( J:181229 )

respiratory system

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

Genotype
MGI:5312870

cn4

• Allelic Composition: Bmp2^tm1Jfm/Bmp2^tm1Jfm; Bmp4^tm1Jfm/Bmp4⁺; Bmp7^tm1Jfm/Bmp7⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

craniofacial

absent alisphenoid bone ( J:181229 )

absent mandibular coronoid process ( J:181229 )

small nasal bone ( J:181229 )

absent zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

skeleton

absent alisphenoid bone ( J:181229 )

absent mandibular coronoid process ( J:181229 )

small nasal bone ( J:181229 )

absent zygomatic bone ( J:181229 )

growth/size/body

small nasal bone ( J:181229 )

cleft palate ( J:181229 )

respiratory system

small nasal bone ( J:181229 )

Genotype
MGI:3628946

cn5

• Allelic Composition: Bmp7^tm6(cre)Rob/Bmp7⁺; Smad4^tm1Rob/Smad4^tm1.1Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:108109 )

• at 1 week of age no pups are found

perinatal lethality, incomplete penetrance ( J:108109 )

• only 7% of pups at P1 are homozygous rather than the expected 25%

renal/urinary system

kidney cyst ( J:108109 )

• sporadic cysts at E17.5 sometimes occurring in Bowman's space

decreased kidney collecting duct number ( J:108109 )

• the number of collecting ducts is reduced to 8 +/- 1 and 9 +/- 2 compared to 20 +/- 2 and 28 +/- 2 in wild-type mice at E14.5 and E16.5, respectively

abnormal renal glomerulus morphology ( J:108109 )

• abnormal clustering of the glomeruli

abnormal kidney development ( J:108109 )

• at E12.0, E14.5, and E16.5 increased cell death is seen in thickened areas of the mesenchyme at the periphery of the kidney; however around the collecting duct tips cell death is similar to wild-type

• at E12.5 expression patterns indicate that few foci of nephrogenic mesenchyme condensations are formed, the stromal cell population is increased, the number of epithelial structures is reduced, and the normal segregation of stoma and mesenchyme is incomplete

• at E12.5 the cortical cell layer is thicker than in wild-type and increased cell death is seen in the cortical regions

• at E14.5 the cell layer between the nephrogenic mesenchyme and the kidney capsule is thicker than in wild-type

• at E14.5 and E16.5 the tips of the collecting ducts are surrounded by variably reduced amounts of nephrogenic mesenchyme with about 50% lacking any surrounding nephrogenic mesenchyme

small kidney ( J:108109 )

• about half the volume of wild-type kidneys at E17.5

hydroureter ( J:108109 )

• at E17.5

growth/size/body

kidney cyst ( J:108109 )

• sporadic cysts at E17.5 sometimes occurring in Bowman's space

Genotype
MGI:3700045

cn6

• Allelic Composition: Bmp2^tm1Cjt/Bmp2⁺; Bmp7^tm1Rob/Bmp7⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants are completely like wild-type in skeletal pattern and differentiation

Genotype
MGI:3700043

cn7

• Allelic Composition: Bmp2^tm1Cjt/Bmp2^tm1Cjt; Bmp7^tm1Rob/Bmp7⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

skeleton

abnormal scapula morphology ( J:118257 )

• mice show a scapular defect

Genotype
MGI:3641531

cx8

• Allelic Composition: Bmp7^tm1Rob/Bmp7⁺; Fbn2^tm1Rmz/Fbn2⁺
• Genetic Background: either: (involves: 129/Sv * 129S/SvEv) or (involves: 129/Sv * 129S/SvEv * C57BL/6J)

limbs/digits/tail

polysyndactyly ( J:70592 )

Genotype
MGI:3047090

cx9

• Allelic Composition: Bmp4^tm1Blh/Bmp4⁺; Bmp7^tm1Kry/Bmp7⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

growth/size/body

growth/size/body region phenotype ( J:48538 )

N • double heterozygotes are viable, fertile and have normal size and weight

N • double heterozygotes have normal size and shape of internal organs and of long bones

limbs/digits/tail

abnormal digit morphology ( J:48538 )

• in one case, digit I was partially triplicated, showing both a complete duplication and a biphalangeal extension of the most anterior extra digit I

• in all cases, none of the extra digits show more than two phalanges but always look like digit I

• no webbing is observed in the affected limbs of double heterozygotes

polydactyly ( J:48538 )

• duplication of the first digit is found at a much higher frequency (50%) in double heterozygotes compared to single Bmp4tm1Blh heterozygotes (18%) or Bmp7 heterozygotes (0%); the penetrance of this duplication is, however, lower in double heterozygotes than in Bmp7 homozygous null mice (67%)

• both in Bmp7 homozygous null mice and double heterozygotes, polydactyly primarily affects the right hindlimb than the left hind- or forelimb; however, effects are also observed bilaterally

• most double heterozygotes exhibit incomplete duplication, and the extra digit extends from metatarsal I

skeleton

abnormal thoracic cage morphology ( J:48538 )

• 44% of double heterozygotes display rib cage defects, including multiple misalignment of the rib pairs

abnormal sternum morphology ( J:48538 )

• as a result of asymmetric rib attachment, the sternum has a sinusoidal appearance in severely affected mice

split xiphoid process ( J:48538 )

• 11% of double heterozygotes have an abnormal xiphoid process: both the cartilaginous and ossified part of the xiphoid process are split medially

asymmetric rib joints ( J:48538 )

• 44% of double heterozygotes display multiple misalignment of the rib pairs

rib fusion ( J:48538 )

• 11% of double heterozygotes display fusion of the ribs; this defect always affects two consecutive costal elements and appears to be limited to a single pair of ribs

Genotype
MGI:2451055

cx10

• Allelic Composition: Bmp7^tm1Rob/Bmp7⁺; Bmp8a^tm1Blh/Bmp8a^tm1Blh
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss

endocrine/exocrine glands

decreased testis weight ( J:78867 )

♂ • average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

reproductive system

decreased testis weight ( J:78867 )

♂ • average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

abnormal epididymis morphology ( J:78867 )

♂ • similar epididymal phenotype as Bmp8a^tm1Blh homozygous mutant mice

Genotype
MGI:2451053

cx11

• Allelic Composition: Bmp7^tm1Rob/Bmp7⁺; Bmp8a^tm1Blh/Bmp8a^tm1Blh
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

immune system

granulomatous inflammation ( J:78867 )

• granuloma formation more pronounced than in Bmp8a^tm1Blh homozygous mutant mice

reproductive system

abnormal male germ cell morphology ( J:78867 )

♂ • higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

abnormal spermatogenesis ( J:78867 )

♂

abnormal epididymis morphology ( J:78867 )

♂ • blockage and accumulation of sperm

epididymis degeneration ( J:78867 )

♂ • 67% exhibited severe epididymal degeneration

epididymis epithelium degeneration ( J:78867 )

♂

male infertility ( J:78867 )

♂ • 75% of male mice were infertile

cellular

abnormal male germ cell morphology ( J:78867 )

♂ • higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

Genotype
MGI:3047104

cx12

• Allelic Composition: Bmp2^tm1Brd/Bmp2⁺; Bmp7^tm1Kry/Bmp7⁺
• Genetic Background: Not Specified

skeleton

skeleton phenotype ( J:48538 )

N • doubly heterozygous pups have a normal skeleton and display no rib cage abnormalities or limb defects