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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx3+
wild type
MGI:2433037
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Stx3Gt(EUCE320f12)1.2Hmgu/Stx3+ B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu MGI:7469801
ht2
 		Stx3tm1.1(KOMP)Vlcg/Stx3+ C57BL/6N-Stx3tm1.1(KOMP)Vlcg/J MGI:5757776


Genotype
MGI:7469801
ht1
Allelic
Composition		 Stx3Gt(EUCE320f12)1.2Hmgu/Stx3+
Genetic
Background		 B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3Gt(EUCE320f12)1.2Hmgu mutation (0 available); any Stx3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:275367 )
N
• in a model of passive systemic anaphylaxis, mice sensitized i.p. with anti-DNP IgE and challenged i.p. with DNP-HAS exhibit a normal hypothermic response at 50 min post-challenge
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

hematopoietic system
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

mortality/aging
mortality/aging ( J:275367 )
N
• mice are viable, grossly normal, and exhibit a normal life span when raised in a specific pathogen-free facility

cellular
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis




Genotype
MGI:5757776
ht2
Allelic
Composition		 Stx3tm1.1(KOMP)Vlcg/Stx3+
Genetic
Background		 C57BL/6N-Stx3tm1.1(KOMP)Vlcg/J
Cell Lines 18654A-F5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3tm1.1(KOMP)Vlcg mutation (1 available); any Stx3 mutation (18 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory