All Phenotypes Tbx4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx4⁺
wild type
MGI:2432976

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx4^tm1.1Kng/Tbx4⁺	involves: 129P2/OlaHsd * C57BL/6J * DBA/2	MGI:3808021
ht2	Tbx4^tm1.1Pa/Tbx4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3609957
ht3	Tbx4^tm1Pa/Tbx4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3609958
cn4	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Tbx4^tm1(cre)Tmj/Tbx4⁺	involves: 129	MGI:5522804
cn5	Efnb2^tm1Henk/Efnb2^tm1Henk Tbx4^tm1(cre)Tmj/Tbx4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5298191

Allelic Composition	Tbx4^tm1.1Kng/Tbx4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx4^tm1.1Kng mutation (0 available); any Tbx4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachydactyly ( J:139169 )

• anterior hindlimb digits are more severely reduced than posterior hindlimb digits compared to in wild-type mice with distal elements more reduced than proximal ones

short femur ( J:139169 )

• mice exhibit short femurs compared to wild-type mice but not as short as in homozygotes

short tibia ( J:139169 )

• mice exhibit short tibias compared to wild-type mice but not as short as in homozygotes

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice but not as short as in homozygotes

skeleton

short femur ( J:139169 )

• mice exhibit short femurs compared to wild-type mice but not as short as in homozygotes

short tibia ( J:139169 )

• mice exhibit short tibias compared to wild-type mice but not as short as in homozygotes

abnormal patella morphology ( J:139169 )

• patellas are shorter than in wild-type mice but not as short as in homozygotes

abnormal pelvic girdle bone morphology ( J:139169 )

• pelvic width is reduced compared to in wild-type mice but not as severely as in homozygotes

Allelic Composition	Tbx4^tm1.1Pa/Tbx4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx4^tm1.1Pa mutation (1 available); any Tbx4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

delayed chorioallantoic fusion ( J:83256 )

• at E8.0, heterozygotes exhibit a delay in chorioallantoic fusion; however, all heterozygous embryos undergo chorioallantoic fusion past the 8-somite stage and appear indistinguishable from wild-type embryos

delayed allantois development ( J:83256 )

• at the 4- to 5-somite stage, heterozygotes display a lag in allantois development relative to somite-matched wild-type embryos dissected at E8.0

Allelic Composition	Tbx4^tm1Pa/Tbx4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx4^tm1Pa mutation (0 available); any Tbx4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

delayed chorioallantoic fusion ( J:83256 )

delayed allantois development ( J:83256 )

• at the 4- to 5-somite stage, heterozygotes display a lag in allantois development relative to somite-matched wild-type embryos dissected at E8.0

Allelic Composition	Robo1^tm1Matl/Robo1^tm1Matl Robo2^tm1Rilm/Robo2^tm1Rilm Tbx4^tm1(cre)Tmj/Tbx4⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Matl mutation (2 available); any Robo1 mutation (88 available)
Robo2^tm1Rilm mutation (1 available); any Robo2 mutation (102 available)
Tbx4^tm1(cre)Tmj mutation (0 available); any Tbx4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:193400 )

• normal lung and diaphragm morphology and normal lung inflation

Allelic Composition	Efnb2^tm1Henk/Efnb2^tm1Henk Tbx4^tm1(cre)Tmj/Tbx4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2^tm1Henk mutation (0 available); any Efnb2 mutation (27 available)
Tbx4^tm1(cre)Tmj mutation (0 available); any Tbx4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:176643 )

N	• mice exhibit normal motor neuron specification and initial phases of motor axon extension

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