Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mcm3+ wild type MGI:2432894 |
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| Summary |
15 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slight but significant reduction in lifespan
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• increased invasiveness of lymphomas
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• mainly lymphomas originating in the mesenteric lymph nodes that in multiple cases infiltrate to other organs
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• earlier onset and increased invasiveness
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• of lymphomas
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slight but significant reduction in lifespan
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• increased invasiveness of lymphomas
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• mainly lymphomas originating in the mesenteric lymph nodes that in multiple cases infiltrate to other organs
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• earlier onset and increased invasiveness
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• of lymphomas
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lifespan is expanded compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice but all mice die by 12 months of age
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• mortality observed in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice is largely rescued
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• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
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| N |
• the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
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• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 MEFs
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• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
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• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4chaos3/Mcm4chaos3 cells but improved 2.5- to 10-fold compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 cells
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| N |
• body weight is rescued compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
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| N |
• lifespan is expanded compared to in Mcm4chaos3 homozygotes
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• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
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• onset of mammary gland tumorigenesis is delayed or eliminated compared with Mcm4chaos3 homozygotes
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• mouse embryonic fibroblasts exhibit increased ability to form induced pluripotent stem cells compared with Mcm4chaos3/Mcm4chaos3 cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die sooner than Mcm4chaos3 homozygotes
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• postnatal mortality observed in Mcm4chaos3/Mcm4Gt(RRE056)Byg mice is partially rescued
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mortality observed in Mcm4chaos3/Mcm4chaos3 Mcm6Gt(YHD248)Byg/Mcm6+ mice is partially rescued
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• tumor latency is shorted than in Mcm4chaos3 homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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