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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcl1+
wild type
MGI:2432872
Summary 3 genotypes


Genotype
MGI:6461424
ht1
Allelic
Composition		 Mcl1em1(IMPC)Mbp/Mcl1+
Genetic
Background		 C57BL/6N-Mcl1em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1em1(IMPC)Mbp mutation (1 available); any Mcl1 mutation (36 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

embryo

growth/size/body
embryonic growth retardation ( J:211773 )
IMPC - UCD

hematopoietic system
small spleen ( J:211773 )
IMPC - UCD

immune system
small spleen ( J:211773 )
IMPC - UCD

nervous system
hydrocephaly ( J:211773 )
IMPC - UCD

vision/eye
microphthalmia ( J:211773 )
IMPC - UCD
anophthalmia ( J:211773 )
IMPC - UCD




Genotype
MGI:4840321
cn2
Allelic
Composition		 Mcl1tm1Dmta/Mcl1+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (3 available); any Gt(ROSA)26Sor mutation (1083 available)
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH

hematopoietic system
decreased germinal center B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following tamoxifen-treatment and immunization with NP-KLH




Genotype
MGI:4840316
cn3
Allelic
Composition		 Mcl1tm1Dmta/Mcl1+
Tg(Aicda-cre)9Mbu/0
Genetic
Background		 B6.Cg-Mcl1tm1Dmta Tg(Aicda-cre)9Mbu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm1Dmta mutation (0 available); any Mcl1 mutation (36 available)
Tg(Aicda-cre)9Mbu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH

hematopoietic system
decreased germinal center B cell number ( J:166069 )
• following immunization with NP-KLH
decreased memory B cell number ( J:166069 )
• following immunization with NP-KLH




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory