Phenotypes associated with this allele

• Allele Symbol: Dad1⁺
• Allele Name: wild type
• Allele ID: MGI:2432840
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dad1^tm1Brw/Dad1^+	involves: 129P2/OlaHsd * Black Swiss	MGI:3639729
ht2	Dad1^tm1Kni/Dad1^+	involves: 129S/SvEv	MGI:3586726

Genotype
MGI:3639729

ht1

• Allelic Composition: Dad1^tm1Brw/Dad1⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:62083 )

N • upon culture, E7.5 heterozygous mutant embryos are slightly under-represented relative to wild-type embryos; however, a normal Mendelian ratio of 2:1 is observed in vivo at weaning

cellular

increased embryonic tissue cell apoptosis ( J:62083 )

• in culture, E7.5 heterozygous mutant embryos show a 2-fold increase in apoptotic cell death relative to wild-type embryos, with variable involvement; however, this difference does not reach statistical significance

embryo

increased embryonic tissue cell apoptosis ( J:62083 )

• in culture, E7.5 heterozygous mutant embryos show a 2-fold increase in apoptotic cell death relative to wild-type embryos, with variable involvement; however, this difference does not reach statistical significance

Genotype
MGI:3586726

ht2

• Allelic Composition: Dad1^tm1Kni/Dad1⁺
• Genetic Background: involves: 129S/SvEv

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:99897 )

• about 20% of heterozygous embryos are lost by E8.5

embryo

embryonic growth retardation ( J:99897 )

• in culture, 4 of 21 heterozygous embryos displayed impaired growth

immune system

decreased thymus weight ( J:99897 )

• the thymus weighs about 10% less than in wild-type mice; however, no difference in body weight is detected

limbs/digits/tail

syndactyly ( J:99897 )

• soft tissue syndactyly, generally as webbing between the second and third digits, is seen in 14% of heterozygotes on the hindlimbs and in 5% of heterozygotes on the forelimbs

• all pups with forelimb syndactyly also have hindlimb deformities

hematopoietic system

decreased thymus weight ( J:99897 )

• the thymus weighs about 10% less than in wild-type mice; however, no difference in body weight is detected

growth/size/body

embryonic growth retardation ( J:99897 )

• in culture, 4 of 21 heterozygous embryos displayed impaired growth

endocrine/exocrine glands

decreased thymus weight ( J:99897 )

• the thymus weighs about 10% less than in wild-type mice; however, no difference in body weight is detected