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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mmp14+
wild type
MGI:2432836
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mmp14tm1Hbh/Mmp14+
Mmp16tm1Khol/Mmp16tm1Khol 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3772055
cx2
 		Mmp14tm1Hbh/Mmp14+
Mmp16tm1Khol/Mmp16+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3772056
cx3
 		Mmp14tm1Noda/Mmp14+
Mmp2tm1Ito/Mmp2tm1Ito 		Not Specified MGI:3046923


Genotype
MGI:3772055
cx1
Allelic
Composition		 Mmp14tm1Hbh/Mmp14+
Mmp16tm1Khol/Mmp16tm1Khol
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Hbh mutation (0 available); any Mmp14 mutation (42 available)
Mmp16tm1Khol mutation (0 available); any Mmp16 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:130212 )
• only 80% of mice survive until weaning

skeleton
decreased cranium length ( J:130212 )
• at day 30, the cranium length is reduced to 86% of wild-type
frontal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the frontal bones
parietal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the parietal bones
thin neurocranium ( J:130212 )
• mice exhibit a thinning of the cranial vault proportional to the loss of wild-type alleles
nasal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the nasal bones
short humerus ( J:130212 )
• severity is proportional to the number of wild-type alleles lost
• at E18.5, humerus cortical length is 87+/-0.7% of wild-type
• at day 20, humerus length is 90+/-0.7% of wild-type
• at day 50, humerus length is 87+/-1% of wild-type
short femur ( J:130212 )
• severity is proportional to the number of wild-type alleles lost
• at E18.5, femur length is 86+/-1% of wild-type
• however, length at day 30 is normal
abnormal compact bone morphology ( J:130212 )
• cortical bone formation is abnormal and the humeri and femora exhibit shortening of the bone cortices proportional to the number of wild-type alleles lost
abnormal chondrocyte morphology ( J:130212 )
• the number of proliferating chondrocytes in the distal femoral epiphysis decreases proportionally to the number of wild-type alleles lost
decreased bone ossification ( J:130212 )
• mice exhibit diminished bone formation

limbs/digits/tail
short humerus ( J:130212 )
• severity is proportional to the number of wild-type alleles lost
• at E18.5, humerus cortical length is 87+/-0.7% of wild-type
• at day 20, humerus length is 90+/-0.7% of wild-type
• at day 50, humerus length is 87+/-1% of wild-type
short femur ( J:130212 )
• severity is proportional to the number of wild-type alleles lost
• at E18.5, femur length is 86+/-1% of wild-type
• however, length at day 30 is normal

craniofacial
decreased cranium length ( J:130212 )
• at day 30, the cranium length is reduced to 86% of wild-type
frontal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the frontal bones
parietal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the parietal bones
thin neurocranium ( J:130212 )
• mice exhibit a thinning of the cranial vault proportional to the loss of wild-type alleles
nasal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the nasal bones
short snout ( J:130212 )
• at day 75 the snout is shorter than in Mmp16tm1Khol homozygotes

growth/size/body
nasal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the nasal bones
short snout ( J:130212 )
• at day 75 the snout is shorter than in Mmp16tm1Khol homozygotes

respiratory system
nasal bone hypoplasia ( J:130212 )
• mice exhibit poor development of the nasal bones




Genotype
MGI:3772056
cx2
Allelic
Composition		 Mmp14tm1Hbh/Mmp14+
Mmp16tm1Khol/Mmp16+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Hbh mutation (0 available); any Mmp14 mutation (42 available)
Mmp16tm1Khol mutation (0 available); any Mmp16 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased cranium length ( J:130212 )
• at day 30, the cranium length is reduced to 91% of wild-type
short humerus ( J:130212 )
• at day 20, humerus length is 94+/-1.2% of wild-type
• at day 50, humerus length is 93+/-0.7% of wild-type
abnormal chondrocyte morphology ( J:130212 )
• the number of proliferating chondrocytes in the distal femoral epiphysis decreases proportionally to the number of wild-type alleles lost

limbs/digits/tail
short humerus ( J:130212 )
• at day 20, humerus length is 94+/-1.2% of wild-type
• at day 50, humerus length is 93+/-0.7% of wild-type

craniofacial
decreased cranium length ( J:130212 )
• at day 30, the cranium length is reduced to 91% of wild-type




Genotype
MGI:3046923
cx3
Allelic
Composition		 Mmp14tm1Noda/Mmp14+
Mmp2tm1Ito/Mmp2tm1Ito
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Noda mutation (0 available); any Mmp14 mutation (42 available)
Mmp2tm1Ito mutation (1 available); any Mmp2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:91198 )
• mutants weigh about 20% less than control littermates but are fertile




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory