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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf12+
wild type
MGI:2432827
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tcf12tm2Zhu/Tcf12+ Not Specified MGI:3709888
cn2
 		Tcf12tm3Zhu/Tcf12+
Tg(EIIa-cre)C5379Lmgd/0
Twist1tm1Bhr/Twist1+ 		involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:8247991
cn3
 		Tcf12tm3Zhu/Tcf12+
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129 * C57BL/6 * FVB/N MGI:8247990
cn4
 		Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3774553
cx5
 		Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3040601
cx6
 		Tcf12tm1Zhu/Tcf12+
Tcf3tm1Wein/Tcf3+ 		involves: 129S4/SvJaeSor MGI:3040599


Genotype
MGI:3709888
ht1
Allelic
Composition		 Tcf12tm2Zhu/Tcf12+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm2Zhu mutation (0 available); any Tcf12 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:120411 )
• at 6 to 12 months of age, ~10-20% of mice show seizure episodes upon handling by the tail

hematopoietic system
hematopoietic system phenotype ( J:120411 )
N
• erythroid and myeloid cell lineages appear normal in heterozygotes

nervous system
seizures ( J:120411 )
• at 6 to 12 months of age, ~10-20% of mice show seizure episodes upon handling by the tail




Genotype
MGI:8247991
cn2
Allelic
Composition		 Tcf12tm3Zhu/Tcf12+
Tg(EIIa-cre)C5379Lmgd/0
Twist1tm1Bhr/Twist1+
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)
Twist1tm1Bhr mutation (4 available); any Twist1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
premature coronal suture closure ( J:198060 )
• mice show severe coronal synostosis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
craniosynostosis DOID:2340 OMIM:182212
OMIM:600593
 J:198060




Genotype
MGI:8247990
cn3
Allelic
Composition		 Tcf12tm3Zhu/Tcf12+
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm3Zhu mutation (1 available); any Tcf12 mutation (75 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:198060 )
N
• mice exhibit normal coronal sutures




Genotype
MGI:3774553
cn4
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (48 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

immune system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells




Genotype
MGI:3040601
cx5
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf4tm1Zhu mutation (1 available); any Tcf4 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally




Genotype
MGI:3040599
cx6
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf3tm1Wein/Tcf3+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (75 available)
Tcf3tm1Wein mutation (0 available); any Tcf3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 70% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 70% reduction in the number of pro-B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory